Standard Name	RCF1 1
Systematic Name	YML030W
Alias	AIM31 2
Feature Type	ORF, Verified
Description	Cytochrome c oxidase subunit; required for assembly of the Complex III-Complex IV supercomplex, and for assembly of Cox13p and Rcf2p into cytochrome c oxidase; similar to Rcf2p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; required for growth under hypoxic conditions; member of the hypoxia induced gene family; C. elegans and human orthologs are functional in yeast (1, 3, 4, 5)
Name Description	Respiratory superComplex Factor 1

Chromosomal Location	ChrXIII:216435 to 216914 | ORF Map | GBrowse

	View Computational GO annotations for RCF1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	mitochondrial respiratory chain complex IV assembly (IGI) mitochondrial respiratory chain supercomplex assembly (IMP)
Cellular Component
Manually curated	integral to mitochondrial inner membrane (IDA) mitochondrial respiratory chain complex IV (IPI) mitochondrial respiratory chain supercomplex (IDA)
High-throughput	mitochondrion (IDA)

Classical genetics
null	reactive oxygen species accumulation: increased oxidative stress resistance: decreased Cox13p accumulation: decreased respiratory growth: decreased vegetative growth: decreased rate
Large-scale survey
null	UV resistance: decreased competitive fitness: decreased dessication resistance: decreased mitochondrial genome maintenance: abnormal resistance to acrolein: decreased respiratory growth: decreased rate viable
overexpression	vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	129 total interaction(s) for 102 unique genes/features.
Physical Interactions	Affinity Capture-MS: 15 Affinity Capture-RNA: 3 Affinity Capture-Western: 20 Biochemical Activity: 1 Two-hybrid: 17
Genetic Interactions	Dosage Growth Defect: 1 Negative Genetic: 60 Phenotypic Enhancement: 1 Positive Genetic: 6 Synthetic Growth Defect: 5
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:216435 to 216914 | ORF Map | GBrowse
Last Update	Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..480 216435..216914 1996-07-31 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004492