TSA1/YML028W Summary 
| Standard Name | TSA1 |
|---|---|
| Systematic Name | YML028W |
| Alias | ZRG14 1 , TPX1 |
| Feature Type | ORF, Verified |
| Description | Thioredoxin peroxidase; acts as both a ribosome-associated and free cytoplasmic antioxidant; self-associates to form a high-molecular weight chaperone complex under oxidative stress; deletion results in mutator phenotype; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress; required for telomere length maintenace; TSA1 has a paralog, TSA2, that arose from the whole genome duplication (2, 3, 4, 5, 6, 7, 8, 9, 10, 11) |
| Name Description | Thiol-Specific Antioxidant 3 |
| Gene Product Alias | cTPxI |
| Chromosomal Location | |
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Gene Ontology Annotations All TSA1 GO evidence and references
| View Computational GO annotations for TSA1 | |
| Molecular Function | |
| Manually curated | |
| Biological Process | |
| Manually curated | |
| Cellular Component | |
| Manually curated | |
| High-throughput |
Mutant phenotypes All TSA1 Phenotype evidence and references
interactions All TSA1 Interaction evidence and references
| 401 total interaction(s) for 230 unique genes/features. | |
| Physical Interactions |
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| Genetic Interactions |
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| Resources |
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Expression Summary
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| Resources |
Protein Information All TSA1 Protein evidence and references
| Localization | |
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| Phosphorylation | PhosphoGRID | PhosphoPep Database |
| Structure | |
| Homologs |
sequence information
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| Last Update | Coordinates: 1996-07-31 | Sequence: 1996-07-31 | ||||||||||||
| Subfeature details |
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| Retrieve sequences | |||||||||||||
Analyze Sequence
| S288C only | |
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| S288C vs. other species | |
| S288C vs. other strains |
Resources
| External Links | All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB |
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| Primary SGDID | S000004490 |
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References cited on this page View Complete Literature Guide for TSA1
| 1) | Yuan DS (2000) Zinc-regulated genes in Saccharomyces cerevisiae revealed by transposon tagging. Genetics 156(1):45-58 |
| 2) | Chae HZ, et al. (1994) Thioredoxin-dependent peroxide reductase from yeast. J Biol Chem 269(44):27670-8 |
| 3) | Chae HZ, et al. (1993) Cloning, sequencing, and mutation of thiol-specific antioxidant gene of Saccharomyces cerevisiae. J Biol Chem 268(22):16815-21 |
| 4) | Wong CM, et al. (2002) Cooperation of yeast peroxiredoxins Tsa1p and Tsa2p in the cellular defense against oxidative and nitrosative stress. J Biol Chem 277(7):5385-94 |
| 5) | Huang ME, et al. (2003) A genomewide screen in Saccharomyces cerevisiae for genes that suppress the accumulation of mutations. Proc Natl Acad Sci U S A 100(20):11529-34 |
| 6) | Wong CM, et al. (2004) Peroxiredoxin-null yeast cells are hypersensitive to oxidative stress and are genomically unstable. J Biol Chem 279(22):23207-13 |
| 7) | Okazaki S, et al. (2005) Peroxiredoxin-mediated redox regulation of the nuclear localization of Yap1, a transcription factor in budding yeast. Antioxid Redox Signal 7(3-4):327-34 |
| 8) | Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61 |
| 9) | Trotter EW, et al. (2008) The yeast Tsa1 peroxiredoxin is a ribosome-associated antioxidant. Biochem J 412(1):73-80 |
| 10) | Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76 |
| 11) | Lu J, et al. (2013) Deletion of the major peroxiredoxin Tsa1 alters telomere length homeostasis. Aging Cell () |
