YOX1/YML027W Summary

YOX1 BASIC INFORMATION

Standard Name	YOX1
Systematic Name	YML027W
Feature Type	ORF, Verified
Description	Homeodomain-containing transcriptional repressor, binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycle-regulated; potential Cdc28p substrate (1, 2, 3)

GO Annotations	All YOX1 GO evidence and references
	View Computational GO annotations for YOX1
Molecular Function
Manually curated	DNA binding (IDA) specific transcriptional repressor activity (IDA, IGI, IMP)
High-throughput	sequence-specific DNA binding (IDA)
Biological Process
Manually curated	negative regulation of transcription from RNA polymerase II promoter (IDA, IGI, IMP) regulation of mitotic cell cycle (IMP)
Cellular Component
Manually curated	nuclear chromatin (IDA) nucleus (IC, IDA)

Regulatory Role
Binding motifs	YOX1 Transcription Factor Binding Sites and References
	YAATTA

Mutant Phenotype	All YOX1 Phenotype details and references
Large-scale survey
null	filamentous growth: decreased invasive growth: absent utilization of carbon source: absent viable
overexpression	vegetative growth: decreased

Interactions	YOX1 All interactions details and references
	5 total interaction(s) for 5 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 1 Affinity Capture-Western: 1 Biochemical Activity: 2 Protein-RNA: 1

Sequence Information

ChrXIII:221406 to 222563 | |

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1158	221406..222563	1996-07-31	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000004489

YOX1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for YOX1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for YOX1]

1)	Kaufmann E (1993) In vitro binding to the leucine tRNA gene identifies a novel yeast homeobox gene. Chromosoma 102(3):174-9
2)	Pramila T, et al. (2002) Conserved homeodomain proteins interact with MADS box protein Mcm1 to restrict ECB-dependent transcription to the M/G1 phase of the cell cycle. Genes Dev 16(23):3034-45
3)	Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64

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