UNG1/YML021C Summary Help

Standard Name UNG1 1
Systematic Name YML021C
Feature Type ORF, Verified
Description Uracil-DNA glycosylase; required for repair of uracil in DNA formed by spontaneous cytosine deamination; efficiently excises uracil from single-stranded DNA in vivo; not required for strand-specific mismatch repair; cell-cycle regulated, expressed in late G1; localizes to mitochondria and nucleus (2, 3, 4, 5, 6)
Name Description Uracil DNA N-Glycosylase 1
Chromosomal Location
ChrXIII:230813 to 229734 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Genetic position: -16 cM
Gene Ontology Annotations All UNG1 GO evidence and references
  View Computational GO annotations for UNG1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 2 genes
Classical genetics
reduction of function
Large-scale survey
43 total interaction(s) for 36 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 1
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Growth Defect: 2
  • Negative Genetic: 13
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 11
  • Positive Genetic: 4
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 1
  • Synthetic Rescue: 7

Expression Summary
Length (a.a.) 359
Molecular Weight (Da) 40,471
Isoelectric Point (pI) 10.29
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrXIII:230813 to 229734 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Genetic position: -16 cM
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..1080 230813..229734 1996-07-31 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004483
References cited on this page View Complete Literature Guide for UNG1
1) Burgers PM and Klein MB  (1986) Selection by genetic transformation of a Saccharomyces cerevisiae mutant defective for the nuclear uracil-DNA-glycosylase. J Bacteriol 166(3):905-13
2) Impellizzeri KJ, et al.  (1991) The spectrum of spontaneous mutations in a Saccharomyces cerevisiae uracil-DNA-glycosylase mutant limits the function of this enzyme to cytosine deamination repair. J Bacteriol 173(21):6807-10
3) Crosby B, et al.  (1981) Purification and characterization of a uracil-DNA glycosylase from the yeast. Saccharomyces cerevisiae. Nucleic Acids Res 9(21):5797-809
4) Johnston LH and Johnson AL  (1995) The DNA repair genes RAD54 and UNG1 are cell cycle regulated in budding yeast but MCB promoter elements have no essential role in the DNA damage response. Nucleic Acids Res 23(12):2147-52
5) Chatterjee A and Singh KK  (2001) Uracil-DNA glycosylase-deficient yeast exhibit a mitochondrial mutator phenotype. Nucleic Acids Res 29(24):4935-40
6) Chan K, et al.  (2012) Base damage within single-strand DNA underlies in vivo hypermutability induced by a ubiquitous environmental agent. PLoS Genet 8(12):e1003149