Standard Name	UBX2 1
Systematic Name	YML013W
Alias	SEL1 2
Feature Type	ORF, Verified
Description	Bridging factor involved in ER-associated protein degradation (ERAD); bridges the cytosolic Cdc48p-Npl1p-Ufd1p ATPase complex and the membrane associated Ssm4p and Hrd1p ubiquitin ligase complexes; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain; redistributes from the ER to lipid droplets during the diauxic shift and stationary phase; required for the maintenance of lipid homeostasis (1, 2, 3, 4, 5)
Name Description	UBiquitin regulatory X 1

Chromosomal Location	ChrXIII:244149 to 245903 | ORF Map | GBrowse

	View Computational GO annotations for UBX2
Molecular Function
Manually curated	protein binding, bridging (IPI)
Biological Process
Manually curated	ER-associated protein catabolic process (IMP, IPI) lipid particle organization (IGI, IMP) proteasomal ubiquitin-dependent protein catabolic process (IMP)
Cellular Component
Manually curated	Doa10p ubiquitin ligase complex (IDA) integral to endoplasmic reticulum membrane (IDA) lipid particle (IDA)
High-throughput	endoplasmic reticulum (IDA) mitochondrial outer membrane (IDA)

Classical genetics
null	tellurium atom accumulation: increased sterol ester accumulation: increased triglyceride accumulation: decreased dessication resistance: decreased lipid particle morphology: abnormal protein secretion: increased CPY* accumulation: increased Lro1p distribution: abnormal Erg1p distribution: abnormal Erg6p distribution: abnormal resistance to ferrozine(2-): decreased resistance to cobalt chloride hexahydrate: decreased resistance to tunicamycin: decreased resistance to mercaptoethanol: decreased resistance to bortezomib: decreased resistance to tellurite: decreased resistance to L-1,4-dithiothreitol: normal starvation resistance: decreased
unspecified	lipid particle morphology: abnormal
Large-scale survey
null	UV resistance: decreased anaerobic growth: decreased auxotrophy competitive fitness: decreased dessication resistance: decreased haploinsufficient protein transport: abnormal resistance to benzo[a]pyrene: increased resistance to amitrole: decreased resistance to (S)-lactic acid: increased resistance to acetic acid: increased resistance to fenpropimorph: increased resistance to tunicamycin: increased resistance to nickel sulfate: decreased resistance to caffeine: decreased resistance to methyl methanesulfonate: decreased resistance to cycloheximide: decreased resistance to hygromycin B: decreased sporulation: decreased stress resistance: increased transposable element transposition: decreased vacuolar morphology: abnormal vegetative growth: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	334 total interaction(s) for 179 unique genes/features.
Physical Interactions	Affinity Capture-MS: 30 Affinity Capture-Western: 20 Biochemical Activity: 1 PCA: 6 Reconstituted Complex: 1 Two-hybrid: 1
Genetic Interactions	Negative Genetic: 141 Phenotypic Enhancement: 12 Phenotypic Suppression: 71 Positive Genetic: 43 Synthetic Growth Defect: 6 Synthetic Lethality: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:244149 to 245903 | ORF Map | GBrowse
Last Update	Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1755 244149..245903 1996-07-31 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004475