Standard Name	ERV25
Systematic Name	YML012W
Feature Type	ORF, Verified
Description	Protein that forms a heterotrimeric complex with Erp1, Erp2p, and Emp24, member of the p24 family involved in endoplasmic reticulum to Golgi transport (1, 2, 3)
Name Description	ER Vesicle

Chromosomal Location	ChrXIII:246116 to 246751 | ORF Map | GBrowse

	View Computational GO annotations for ERV25
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	ER to Golgi vesicle-mediated transport (IPI)
Cellular Component
Manually curated	ER to Golgi transport vesicle (IDA)

Classical genetics
null	Gas1p modification: decreased resistance to L-1,4-dithiothreitol: normal resistance to mercaptoethanol: decreased resistance to tunicamycin: decreased
Large-scale survey
null	UV resistance: decreased competitive fitness: decreased dessication resistance: decreased endocytosis: decreased haploinsufficient protein transport: abnormal resistance to tunicamycin: decreased resistance to clioquinol: decreased resistance to caffeine: increased resistance to (S)-lactic acid: increased resistance to fluconazole: increased stress resistance: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	241 total interaction(s) for 140 unique genes/features.
Physical Interactions	Affinity Capture-MS: 35 Affinity Capture-RNA: 2 Affinity Capture-Western: 6 Biochemical Activity: 1 Co-fractionation: 2 Co-purification: 3 PCA: 51 Reconstituted Complex: 4
Genetic Interactions	Negative Genetic: 66 Phenotypic Enhancement: 15 Phenotypic Suppression: 36 Positive Genetic: 13 Synthetic Growth Defect: 4 Synthetic Lethality: 2 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:246116 to 246751 | ORF Map | GBrowse
Last Update	Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..636 246116..246751 1996-07-31 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004473