YPT7/YML001W Summary Help

YPT7 BASIC INFORMATION

Standard Name YPT7 1
Systematic Name YML001W
Alias AST4 , VAM4 2
Feature Type ORF, Verified
Description GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion, similar to mammalian Rab7 (1, 3, 4, 5)
Name Description Yeast Protein Two 6
GO Annotations All YPT7 GO evidence and references
    View Computational GO annotations for YPT7
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All YPT7 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions YPT7 All interactions details and references
61 total interaction(s) for 40 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 14
  • Biochemical Activity: 4
  • Co-fractionation: 3
  • Co-localization: 1
  • PCA: 2
  • Reconstituted Complex: 4
  • Two-hybrid: 8
Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 6
  • Phenotypic Suppression: 2
  • Synthetic Growth Defect: 5
  • Synthetic Lethality: 5
  • Synthetic Rescue: 2
Sequence Information
ChrXIII:267174 to 267800 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..627 267174..267800 1996-07-31 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000004460

YPT7 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Protein Info & Structure
  • Localization Resources
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  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for YPT7

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for YPT7]

1) Wichmann H, et al.  (1992) Endocytosis in yeast: evidence for the involvement of a small GTP-binding protein (Ypt7p). Cell 71(7):1131-42
2) Wada Y, et al.  (1992) Genes for directing vacuolar morphogenesis in Saccharomyces cerevisiae. I. Isolation and characterization of two classes of vam mutants. J Biol Chem 267(26):18665-70
3) Schimmoller F and Riezman H  (1993) Involvement of Ypt7p, a small GTPase, in traffic from late endosome to the vacuole in yeast. J Cell Sci 106 ( Pt 3):823-30
4) Haas A, et al.  (1995) The GTPase Ypt7p of Saccharomyces cerevisiae is required on both partner vacuoles for the homotypic fusion step of vacuole inheritance. EMBO J 14(21):5258-70
5) Collins KM, et al.  (2005) Sec17p and HOPS, in distinct SNARE complexes, mediate SNARE complex disruption or assembly for fusion. EMBO J 24(10):1775-86
6) Lazar T, et al.  (1997) Vesicular transport: how many Ypt/Rab-GTPases make a eukaryotic cell? Trends Biochem Sci 22(12):468-72