Standard Name	FPR4 1
Systematic Name	YLR449W
Feature Type	ORF, Verified
Description	Peptidyl-prolyl cis-trans isomerase (PPIase); proline isomerase localized to nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones; FPR4 has a paralog, FPR3, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description	FKBP Proline Rotamase (isomerase) 1

Chromosomal Location	ChrXII:1030834 to 1032012 | ORF Map | GBrowse

	View Computational GO annotations for FPR4
Molecular Function
Manually curated	macrolide binding (IDA) peptidyl-prolyl cis-trans isomerase activity (IDA)
Biological Process
Manually curated	chromatin silencing at rDNA (IMP) histone peptidyl-prolyl isomerization (IDA) negative regulation of histone H3-K36 methylation (IMP) nucleosome assembly (IDA) regulation of transcription by chromatin organization (IMP)
Cellular Component
Manually curated	colocalizes_with chromatin (IDA) nucleus (IDA)
High-throughput	nucleolus (IDA)

Classical genetics
null	viable
Large-scale survey
null	competitive fitness: normal haploinsufficient vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	120 total interaction(s) for 84 unique genes/features.
Physical Interactions	Affinity Capture-MS: 73 Affinity Capture-RNA: 2 Co-purification: 1 PCA: 7 Reconstituted Complex: 4 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 26 Positive Genetic: 3 Synthetic Growth Defect: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:1030834 to 1032012 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1179 1030834..1032012 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004441