GMC2/YLR445W Summary Help

Standard Name GMC2 1
Systematic Name YLR445W
Feature Type ORF, Verified
Description Protein involved in meiotic crossing over; component of the Synaptonemal Complex (SC) along with Ecm11p; required for the efficient loading of the SC transverse filament protein, Zip1p; promotes SUMOylation of Ecm11p; mutants are delayed in meiotic nuclear division and are defective in synaptonemal complex assembly; transcription is regulated by Ume6p and induced in response to alpha factor (1, 2, 3, 4)
Name Description Grand Meiotic recombination Cluster 5
Chromosomal Location
ChrXII:1024189 to 1024837 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All GMC2 GO evidence and references
  View Computational GO annotations for GMC2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 2 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
14 total interaction(s) for 11 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 2
  • Two-hybrid: 1

Genetic Interactions
  • Negative Genetic: 8
  • Phenotypic Suppression: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 188
Molecular Weight (Da) 22,365
Isoelectric Point (pI) 4.62
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:1024189 to 1024837 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2004-02-03
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..384 1024189..1024572 2011-02-03 2004-02-03
Intron 385..466 1024573..1024654 2011-02-03 2004-02-03
CDS 467..649 1024655..1024837 2011-02-03 2004-02-03
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004437
References cited on this page View Complete Literature Guide for GMC2
1) Brar GA, et al.  (2012) High-resolution view of the yeast meiotic program revealed by ribosome profiling. Science 335(6068):552-7
2) Roberts CJ, et al.  (2000) Signaling and circuitry of multiple MAPK pathways revealed by a matrix of global gene expression profiles. Science 287(5454):873-80
3) Williams RM, et al.  (2002) The Ume6 regulon coordinates metabolic and meiotic gene expression in yeast. Proc Natl Acad Sci U S A 99(21):13431-6
4) Humphryes N, et al.  (2013) The Ecm11-Gmc2 complex promotes synaptonemal complex formation through assembly of transverse filaments in budding yeast. PLoS Genet 9(1):e1003194
5) Brar G  (2012) personal communication