Standard Name	CNA1 1
Systematic Name	YLR433C
Alias	CMP1 2
Feature Type	ORF, Verified
Description	Calcineurin A; one isoform (the other is Cmp2p) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1; CNA1 has a paralog, CMP2, that arose from the whole genome duplication (3, 4, 5, 6)
Name Description	CalciNeurin A 1

Chromosomal Location	ChrXII:1006008 to 1004347 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for CNA1
Molecular Function
Manually curated	contributes_to calcium-dependent protein serine/threonine phosphatase activity (IDA)
Biological Process
Manually curated	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion (IMP) cellular ion homeostasis (IMP) fungal-type cell wall organization (IGI, IMP)
Cellular Component
Manually curated	calcineurin complex (IDA, IPI) cytoplasm (TAS)

Regulatory modules	predicted: stressResponse (637, 541, 397)

Classical genetics
null	calcium(2+) accumulation: increased recovery from pheromone-induced cell cycle arrest: normal resistance to FK520: normal resistance to cyclosporin A: increased resistance to Plakortide F Acid: decreased viability: decreased viable
unspecified	resistance to cyclosporin A: normal resistance to FK506: increased resistance to cyclosporin A: increased resistance to FK506 and cyclosporin A: increased
Large-scale survey
null	competitive fitness: decreased haploinsufficient resistance to sodium arsenite: decreased resistance to quinine: decreased stress resistance: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	84 total interaction(s) for 58 unique genes/features.
Physical Interactions	Affinity Capture-MS: 23 Affinity Capture-RNA: 1 Affinity Capture-Western: 3 Biochemical Activity: 1 Co-crystal Structure: 1 Co-purification: 1 Reconstituted Complex: 3 Two-hybrid: 18
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 6 Negative Genetic: 15 Positive Genetic: 2 Synthetic Growth Defect: 5 Synthetic Lethality: 3 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:1006008 to 1004347 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1662 1006008..1004347 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004425