TUS1/YLR425W Summary Help

Standard Name TUS1 1
Systematic Name YLR425W
Alias SOP10
Feature Type ORF, Verified
Description Guanine nucleotide exchange factor (GEF) that modulate Rho1p activity; involved in the cell integrity signaling pathway; interacts with Rgl1p; localization of Tus1p to the bed neck is regulated by Rgl1p; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate (1, 2, 3, 4)
Name Description TOR Unique function Suppressor 1
Chromosomal Location
ChrXII:982894 to 986817 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All TUS1 GO evidence and references
  View Computational GO annotations for TUS1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
96 total interaction(s) for 69 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 7
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 4
  • Biochemical Activity: 2
  • Co-localization: 1
  • PCA: 1
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Rescue: 9
  • Negative Genetic: 10
  • Phenotypic Suppression: 9
  • Positive Genetic: 1
  • Synthetic Growth Defect: 9
  • Synthetic Lethality: 40
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,307
Molecular Weight (Da) 149,111
Isoelectric Point (pI) 6.83
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:982894 to 986817 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..3924 982894..986817 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004417
References cited on this page View Complete Literature Guide for TUS1
1) Schmelzle T, et al.  (2002) Yeast protein kinases and the RHO1 exchange factor TUS1 are novel components of the cell integrity pathway in yeast. Mol Cell Biol 22(5):1329-39
2) Helliwell SB, et al.  (1998) TOR2 is part of two related signaling pathways coordinating cell growth in Saccharomyces cerevisiae. Genetics 148(1):99-112
3) Ubersax JA, et al.  (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
4) Krause SA, et al.  (2012) Functional specialisation of yeast Rho1 GTP exchange factors. J Cell Sci 125(Pt 11):2721-31