Standard Name	PUN1 1
Systematic Name	YLR414C
Feature Type	ORF, Verified
Description	Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress (2, 3, 4, 5)
Name Description	Plasma membrane protein Upregulated during Nitrogen stress 1

Chromosomal Location	ChrXII:954144 to 953353 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for PUN1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	fungal-type cell wall organization (IMP) protein oligomerization (IDA)
Cellular Component
Manually curated	colocalizes_with membrane raft (IDA) plasma membrane (IDA)
High-throughput	cellular bud (IDA) cytoplasm (IDA) integral to membrane (ISM)

Classical genetics
null	cell wall morphology: abnormal cellular morphology: abnormal invasive growth: decreased metal resistance: decreased pseudohyphal growth: absent vegetative growth: decreased
Large-scale survey
null	acid pH resistance: decreased competitive fitness: increased haploinsufficient metal resistance: decreased resistance to ethanol: decreased resistance to 1,4-dithiothreitol: decreased resistance to tunicamycin: decreased thermotolerance: decreased viable
overexpression	vegetative growth: decreased rate vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	21 total interaction(s) for 19 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 Affinity Capture-RNA: 4 Affinity Capture-Western: 1 Protein-RNA: 1 Reconstituted Complex: 1
Genetic Interactions	Negative Genetic: 8 Positive Genetic: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder | YeastRC Mass Spec

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:954144 to 953353 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..792 954144..953353 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004406