FLD1/YLR404W Summary Help

Standard Name FLD1 1
Systematic Name YLR404W
Feature Type ORF, Verified
Description Seipin protein; involved in lipid droplet morphology, number, and size; proposed to be involved in lipid metabolism; related to the human BSCL2 which is associated with lipodystrophy (1, 2)
Name Description Few Lipid Droplets 1
Gene Product Alias seipin 2
Chromosomal Location
ChrXII:928743 to 929600 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All FLD1 GO evidence and references
  View Computational GO annotations for FLD1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 2 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
63 total interaction(s) for 51 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 3
  • Two-hybrid: 2

Genetic Interactions
  • Negative Genetic: 41
  • Positive Genetic: 10
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 1
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 285
Molecular Weight (Da) 32,590
Isoelectric Point (pI) 7.77
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:928743 to 929600 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..858 928743..929600 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Retired NameSEI1
Primary SGDIDS000004396
References cited on this page View Complete Literature Guide for FLD1
1) Fei W, et al.  (2008) Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast. J Cell Biol 180(3):473-82
2) Szymanski KM, et al.  (2007) The lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphology. Proc Natl Acad Sci U S A 104(52):20890-5