Standard Name	VID22 1
Systematic Name	YLR373C
Feature Type	ORF, Verified
Description	Glycosylated integral membrane protein localized to plasma membrane; plays a role in fructose-1,6-bisphosphatase (FBPase) degradation; involved in FBPase transport from the cytosol to Vid (vacuole import and degradation) vesicles; VID22 has a paralog, ENV11, that arose from the whole genome duplication (1, 2, 3)
Name Description	Vacuolar Import and Degradation 1

Chromosomal Location	ChrXII:871367 to 868662 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for VID22
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	vacuolar protein catabolic process (IMP)
Cellular Component
Manually curated	integral to plasma membrane (IDA)

Classical genetics
null	chromosome/plasmid maintenance: abnormal viable
unspecified	FBP1 accumulation: increased
Large-scale survey
null	auxotrophy cell cycle progression in G1 phase: increased duration glycogen accumulation: increased glutathione excretion: increased competitive fitness: decreased dessication resistance: decreased haploinsufficient heat sensitivity: increased ionic stress resistance: decreased resistance to 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid: decreased resistance to mycophenolic acid: increased resistance to fenpropimorph: increased resistance to caffeine: increased resistance to camptothecin: increased resistance to hydroxyurea: decreased resistance to formaldehyde: decreased resistance to fluconazole: decreased resistance to sodium arsenite: decreased resistance to propolis extract: decreased resistance to quinine: decreased resistance to 4-chlorophenol: decreased resistance to hygromycin B: decreased resistance to spermine: decreased resistance to bleomycin: decreased resistance to methyl methanesulfonate: decreased resistance to tunicamycin: decreased resistance to dimethyl sulfoxide: decreased resistance to fluconazole: increased resistance to doxorubicin: decreased sporulation: normal sporulation efficiency: increased starvation resistance: decreased stress resistance: decreased toxin resistance: decreased vacuolar morphology: abnormal viable
overexpression	resistance to sirolimus: increased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	332 total interaction(s) for 242 unique genes/features.
Physical Interactions	Affinity Capture-MS: 9 Affinity Capture-RNA: 2 Affinity Capture-Western: 2 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 196 Phenotypic Suppression: 1 Positive Genetic: 57 Synthetic Growth Defect: 47 Synthetic Lethality: 16
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:871367 to 868662 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2706 871367..868662 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004365