ELO3/YLR372W Summary Help

Standard Name ELO3 1
Systematic Name YLR372W
Alias SRE1 , VBM1 2 , APA1 , SUR4 3
Feature Type ORF, Verified
Description Elongase; involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis (1, 4)
Name Description fatty acid ELOngation 1
Chromosomal Location
ChrXII:867354 to 868391 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All ELO3 GO evidence and references
  View Computational GO annotations for ELO3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 9 genes
Resources
Pathways
Classical genetics
null
overexpression
unspecified
Large-scale survey
null
overexpression
Resources
663 total interaction(s) for 436 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 10
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 1
  • Biochemical Activity: 1
  • Co-purification: 1
  • PCA: 82

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 239
  • Phenotypic Enhancement: 7
  • Phenotypic Suppression: 81
  • Positive Genetic: 171
  • Synthetic Growth Defect: 14
  • Synthetic Lethality: 9
  • Synthetic Rescue: 44

Resources
Expression Summary
histogram
Resources
Length (a.a.) 345
Molecular Weight (Da) 39,465
Isoelectric Point (pI) 10.13
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:867354 to 868391 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1038 867354..868391 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004364
References cited on this page View Complete Literature Guide for ELO3
1) Oh CS, et al.  (1997) ELO2 and ELO3, homologues of the Saccharomyces cerevisiae ELO1 gene, function in fatty acid elongation and are required for sphingolipid formation. J Biol Chem 272(28):17376-84
2) David D, et al.  (1998) Involvement of long chain fatty acid elongation in the trafficking of secretory vesicles in yeast. J Cell Biol 143(5):1167-82
3) Desfarges L, et al.  (1993) Yeast mutants affected in viability upon starvation have a modified phospholipid composition. Yeast 9(3):267-77
4) Kobayashi SD and Nagiec MM  (2003) Ceramide/long-chain base phosphate rheostat in Saccharomyces cerevisiae: regulation of ceramide synthesis by Elo3p and Cka2p. Eukaryot Cell 2(2):284-94