Standard Name	ROM2 1
Systematic Name	YLR371W
Feature Type	ORF, Verified
Description	GDP/GTP exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF; Rom2p localization to the bud surface is dependent on Ack1p; ROM2 has a paralog, ROM1, that arose from the whole genome duplication (1, 2, 3)
Name Description	RhO1 Multicopy suppressor 1

Chromosomal Location	ChrXII:862714 to 866784 | ORF Map | GBrowse

	View Computational GO annotations for ROM2
Molecular Function
Manually curated	phosphatidylinositol-4,5-bisphosphate binding (IDA) Rho guanyl-nucleotide exchange factor activity (IDA, IPI) signal transducer activity (IGI)
Biological Process
Manually curated	activation of Rho GTPase activity (IDA) establishment of cell polarity (IMP) negative regulation of cAMP-mediated signaling (IGI, IMP) positive regulation of endocytosis (IMP) regulation of fungal-type cell wall organization (IGI) small GTPase mediated signal transduction (IPI)
Cellular Component
Manually curated	cellular bud tip (IDA) incipient cellular bud site (IDA) mating projection tip (IDA)

Regulatory modules	predicted: cellcycle (239)

Classical genetics
null	bud morphology: abnormal budding index: increased cell cycle progression in G1 phase: increased duration cell size: increased cold sensitivity: increased critical cell size at START (G1 cell-size checkpoint): decreased heat sensitivity: increased mating projection morphology: abnormal replicative lifespan: increased resistance to ethanol: decreased resistance to Calcofluor White: decreased resistance to arsenate ion: decreased resistance to benomyl: decreased resistance to enzymatic treatment: decreased
unspecified	resistance to caffeine: decreased
Large-scale survey
null	auxotrophy budding pattern: abnormal cell shape: abnormal cell size: decreased cell size: increased competitive fitness: decreased dessication resistance: decreased endocytosis: decreased fermentative growth: decreased rate haploinsufficient heat sensitivity: increased inviable Fus-Mid-GFP distribution: abnormal replicative lifespan: increased resistance to calcofluor white: decreased resistance to ethanol: decreased resistance to tunicamycin: decreased resistance to sodium arsenite: decreased resistance to propolis extract: decreased resistance to dimethyl sulfoxide: decreased resistance to quinine: decreased resistance to caffeine: decreased resistance to acrolein: decreased starvation resistance: decreased vacuolar morphology: abnormal viable
unspecified	resistance to Calcofluor White: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	333 total interaction(s) for 239 unique genes/features.
Physical Interactions	Affinity Capture-MS: 26 Affinity Capture-RNA: 2 Affinity Capture-Western: 4 Biochemical Activity: 3 Co-localization: 1 PCA: 3 Two-hybrid: 5
Genetic Interactions	Dosage Rescue: 29 Negative Genetic: 122 Phenotypic Enhancement: 4 Phenotypic Suppression: 8 Positive Genetic: 11 Synthetic Growth Defect: 25 Synthetic Lethality: 71 Synthetic Rescue: 19
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:862714 to 866784 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..4071 862714..866784 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004363