ROM2/YLR371W Summary

ROM2 BASIC INFORMATION

Standard Name	ROM2 1
Systematic Name	YLR371W
Feature Type	ORF, Verified
Description	GDP/GTP exchange protein (GEP) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEP (1)
Name Description	RhO1 Multicopy suppressor 1

GO Annotations	All ROM2 GO evidence and references
	View Computational GO annotations for ROM2
Molecular Function
Manually curated	phosphatidylinositol-4,5-bisphosphate binding (IDA) Rho guanyl-nucleotide exchange factor activity (IDA, IPI)
Biological Process
Manually curated	actin filament organization (TAS) budding cell bud growth (TAS) establishment of cell polarity (TAS) fungal-type cell wall organization (TAS) positive regulation of endocytosis (IMP) response to stress (IMP) small GTPase mediated signal transduction (TAS)
Cellular Component
Manually curated	cellular bud tip (TAS)

Regulatory Role
Regulatory modules	predicted: cellcycle ( 239 )

Mutant Phenotype	All ROM2 Phenotype details and references
Classical genetics
null	replicative lifespan: increased resistance to ethanol: decreased resistance to Calcofluor White: decreased resistance to benomyl: decreased resistance to enzymatic treatment: decreased
Large-scale survey
null	budding pattern: abnormal cell shape: abnormal cell size: increased competitive fitness: decreased fermentative growth: decreased rate replicative lifespan: increased resistance to caffeine: decreased resistance to ethanol: decreased resistance to calcofluor white: decreased viable

Interactions	ROM2 All interactions details and references
	111 total interaction(s) for 73 unique genes/features.
Physical Interactions	Affinity Capture-MS: 23 Affinity Capture-RNA: 2 Biochemical Activity: 2 PCA: 2 Two-hybrid: 3
Genetic Interactions	Dosage Rescue: 20 Phenotypic Enhancement: 3 Phenotypic Suppression: 4 Synthetic Growth Defect: 14 Synthetic Lethality: 25 Synthetic Rescue: 13

Sequence Information

ChrXII:862713 to 866783 | |

Last Update

Coordinates: 2004-02-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..4071	862713..866783	2004-02-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000004363

ROM2 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for ROM2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for ROM2]

1)	Ozaki K, et al. (1996) Rom1p and Rom2p are GDP/GTP exchange proteins (GEPs) for the Rho1p small GTP binding protein in Saccharomyces cerevisiae. EMBO J 15(9):2196-207

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