ARC18/YLR370C Summary

ARC18 BASIC INFORMATION

Standard Name	ARC18 1
Systematic Name	YLR370C
Feature Type	ORF, Verified
Description	Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches (1, 2)
Name Description	ARp2/3 Complex subunit 1

GO Annotations	All ARC18 GO evidence and references
	View Computational GO annotations for ARC18
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	actin filament organization (IMP) establishment of mitochondrion localization (IMP) mitochondrion inheritance (TAS)
Cellular Component
Manually curated	Arp2/3 protein complex (IDA) mitochondrion (IDA)

Mutant Phenotype	All ARC18 Phenotype details and references
Classical genetics
null	actin cytoskeleton morphology: abnormal mitochondrial morphology: abnormal carboxypeptidase Y (Prc1p) modification: decreased
Large-scale survey
null	bud morphology: abnormal inositols excretion: increased chitin deposition: increased chromosome/plasmid maintenance: decreased competitive fitness: decreased fermentative growth: decreased rate resistance to Calcofluor White: normal resistance to monensin: decreased resistance to selenomethionine: increased resistance to 5-fluorouracil: decreased resistance to benomyl: decreased sporulation: decreased viable

Interactions	ARC18 All interactions details and references
	115 total interaction(s) for 62 unique genes/features.
Physical Interactions	Affinity Capture-MS: 38 Affinity Capture-RNA: 1 Affinity Capture-Western: 7 Co-localization: 1 Co-purification: 6 FRET: 1 PCA: 10
Genetic Interactions	Synthetic Growth Defect: 17 Synthetic Haploinsufficiency: 1 Synthetic Lethality: 33

Sequence Information

ChrXII:862253 to 861717 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2004-02-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..537	862253..861717	2004-02-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000004362

ARC18 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for ARC18

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for ARC18]

1)	Winter D, et al. (1997) The complex containing actin-related proteins Arp2 and Arp3 is required for the motility and integrity of yeast actin patches. Curr Biol 7(7):519-29
2)	Winter DC, et al. (1999) Genetic dissection of the budding yeast Arp2/3 complex: a comparison of the in vivo and structural roles of individual subunits. Proc Natl Acad Sci U S A 96(13):7288-93

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