| Standard Name | GRX8 1 |
|---|---|
| Systematic Name | YLR364W |
| Feature Type | ORF, Verified |
| Description | Glutaredoxin that employs a dithiol mechanism of catalysis; monomeric; activity is low and null mutation does not affect sensitivity to oxidative stress; GFP-fusion protein localizes to the cytoplasm; expression strongly induced by arsenic (1, 2, 3, 4, 5) |
| Name Description | GlutaRedoXin 1 |
| Chromosomal Location | |
|---|---|
Gene Ontology Annotations All GRX8 GO evidence and references
| View Computational GO annotations for GRX8 | |
| Molecular Function | |
| Manually curated | |
| Biological Process | |
| Manually curated |
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| Cellular Component | |
| High-throughput |
Mutant phenotypes All GRX8 Phenotype evidence and references
| Large-scale survey | |
|---|---|
| null | |
| Resources |
interactions All GRX8 Interaction evidence and references
| 2 total interaction(s) for 2 unique genes/features. | |
| Genetic Interactions |
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| Resources |
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Expression Summary
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| Resources |
Protein Information All GRX8 Protein evidence and references
| Localization | |
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| Phosphorylation | PhosphoGRID | PhosphoPep Database |
| Structure | |
| Homologs |
sequence information
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| Last Update | Coordinates: 2011-02-03 | Sequence: 1996-07-31 | ||||||||||||
| Subfeature details |
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Analyze Sequence
| S288C only | |
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| S288C vs. other species | |
| S288C vs. other strains |
Resources
| External Links | All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB |
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| Primary SGDID | S000004356 |
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References cited on this page View Complete Literature Guide for GRX8
| 1) | Mesecke N, et al. (2008) Two Novel Monothiol Glutaredoxins from Saccharomyces cerevisiae Provide Further Insight into Iron-Sulfur Cluster Binding, Oligomerization, and Enzymatic Activity of Glutaredoxins. Biochemistry 47(5):1452-63 |
| 2) | Giaever G, et al. (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91 |
| 3) | Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 |
| 4) | Haugen AC, et al. (2004) Integrating phenotypic and expression profiles to map arsenic-response networks. Genome Biol 5(12):R95 |
| 5) | Eckers E, et al. (2009) Biochemical characterization of dithiol glutaredoxin 8 from Saccharomyces cerevisiae: the catalytic redox mechanism redux. Biochemistry 48(6):1410-23 |






