Standard Name	DCR2 1
Systematic Name	YLR361C
Feature Type	ORF, Verified
Description	Phosphoesterase involved in downregulation of the unfolded protein response, at least in part via dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START (1, 2)
Name Description	Dose-dependent Cell cycle Regulator 1

Chromosomal Location	ChrXII:849124 to 847388 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for DCR2
Molecular Function
Manually curated	hydrolase activity, acting on ester bonds (IMP, ISS) phosphoprotein phosphatase activity (IDA, IMP) phosphoric ester hydrolase activity (IDA)
Biological Process
Manually curated	endoplasmic reticulum unfolded protein response (IGI, IMP) protein dephosphorylation (IDA, IMP) traversing start control point of mitotic cell cycle (IMP)
Cellular Component
Manually curated	cellular_component unknown (ND)

Classical genetics
dominant negative	hyperosmotic stress resistance: decreased
null	budding index: normal pro-CPY accumulation: increased
overexpression	budding index: increased colony sectoring: increased Sic1p-TAG accumulation: decreased
unspecified	sterol accumulation: decreased
Large-scale survey
null	resistance to sodium selenide: decreased resistance to cycloheximide: decreased resistance to dimethyl sulfoxide: decreased vacuolar morphology: abnormal viable
overexpression	resistance to sirolimus: decreased vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	85 total interaction(s) for 61 unique genes/features.
Physical Interactions	Affinity Capture-Western: 2 Biochemical Activity: 2
Genetic Interactions	Negative Genetic: 58 Phenotypic Enhancement: 4 Positive Genetic: 3 Synthetic Growth Defect: 3 Synthetic Lethality: 13
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:849124 to 847388 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1737 849124..847388 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004353