VPS38/YLR360W Summary

VPS38 BASIC INFORMATION

Standard Name	VPS38 1, 2
Systematic Name	YLR360W
Alias	VPL17 2
Feature Type	ORF, Verified
Description	Part of a Vps34p phosphatidylinositol 3-kinase complex that functions in carboxypeptidase Y (CPY) sorting; binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate (PtdIns3P) which stimulates kinase activity (3, 4)
Name Description	Vacuolar Protein Sorting 1, 2

GO Annotations	All VPS38 GO evidence and references
	View Computational GO annotations for VPS38
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	ER-associated protein catabolic process (IMP) late endosome to vacuole transport (IGI, IMP)
Cellular Component
Manually curated	phosphatidylinositol 3-kinase complex II (IDA)

Mutant Phenotype	All VPS38 Phenotype details and references
Classical genetics
null	1-phosphatidyl-1D-myo-inositol 3-phosphates accumulation: decreased Pep1p-HA distribution: abnormal Kex2p-GFP distribution: abnormal Vps5p-GFP distribution: abnormal Vps17p-GFP distribution: abnormal
reduction of function	vacuolar transport: abnormal
Large-scale survey
null	inositols excretion: increased competitive fitness: decreased metal resistance: decreased Pho8p (ALP) modification: decreased Cps1p (CPS) modification: decreased resistance to rapamycin: decreased resistance to wortmannin: increased resistance to calcium dichloride: decreased resistance to hygromycin B: decreased resistance to nickel(2+): increased resistance to ethanol: decreased resistance to nickel sulfate: increased viable

Interactions	VPS38 All interactions details and references
	28 total interaction(s) for 20 unique genes/features.
Physical Interactions	Affinity Capture-MS: 8 Affinity Capture-Western: 4 PCA: 1
Genetic Interactions	Synthetic Growth Defect: 4 Synthetic Lethality: 10 Synthetic Rescue: 1

Sequence Information

ChrXII:846102 to 847421 | |

Last Update

Coordinates: 2004-02-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1320	846102..847421	2004-02-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000004352

VPS38 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for VPS38

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for VPS38]

1)	Robinson JS, et al. (1988) Protein sorting in Saccharomyces cerevisiae: isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases. Mol Cell Biol 8(11):4936-48
2)	Rothman JH, et al. (1989) Characterization of genes required for protein sorting and vacuolar function in the yeast Saccharomyces cerevisiae. EMBO J 8(7):2057-65
3)	Kihara A, et al. (2001) Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae. J Cell Biol 152(3):519-30
4)	Burda P, et al. (2002) Retromer function in endosome-to-Golgi retrograde transport is regulated by the yeast Vps34 PtdIns 3-kinase. J Cell Sci 115(Pt 20):3889-900

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