ILV5/YLR355C Summary Help

Standard Name ILV5 1
Systematic Name YLR355C
Feature Type ORF, Verified
Description Acetohydroxyacid reductoisomerase and mtDNA binding protein; involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondrial DNA; found in mitochondrial nucleoids (1, 2, 3, 4)
Name Description IsoLeucine-plus-Valine requiring 1
Chromosomal Location
ChrXII:839253 to 838066 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: 252 cM
Gene Ontology Annotations All ILV5 GO evidence and references
  View Computational GO annotations for ILV5
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 25 genes
Resources
Pathways
Classical genetics
null
reduction of function
Large-scale survey
null
reduction of function
unspecified
Resources
51 total interaction(s) for 43 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 30
  • Affinity Capture-RNA: 8
  • Co-fractionation: 1

Genetic Interactions
  • Dosage Rescue: 2
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 4
  • Synthetic Lethality: 2
  • Synthetic Rescue: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 395
Molecular Weight (Da) 44,368
Isoelectric Point (pI) 9.83
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:839253 to 838066 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Genetic position: 252 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1188 839253..838066 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004347
References cited on this page View Complete Literature Guide for ILV5
1) Petersen JG and Holmberg S  (1986) The ILV5 gene of Saccharomyces cerevisiae is highly expressed. Nucleic Acids Res 14(24):9631-51
2) Zelenaya-Troitskaya O, et al.  (1995) An enzyme in yeast mitochondria that catalyzes a step in branched-chain amino acid biosynthesis also functions in mitochondrial DNA stability. EMBO J 14(13):3268-76
3) Park S, et al.  (2006) Yme2p is a mediator of nucleoid structure and number in mitochondria of the yeast Saccharomyces cerevisiae. Curr Genet 50(3):173-82
4) Macierzanka M, et al.  (2008) Maintenance and stabilization of mtDNA can be facilitated by the DNA-binding activity of Ilv5p. Biochim Biophys Acta 1783(1):107-17