DIC1/YLR348C Summary Help

Standard Name DIC1 1
Systematic Name YLR348C
Feature Type ORF, Verified
Description Mitochondrial dicarboxylate carrier; integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix (2, 3)
Name Description DIcarboxylate Carrier 4
Chromosomal Location
ChrXII:827873 to 826977 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All DIC1 GO evidence and references
  View Computational GO annotations for DIC1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 17 genes
Resources
Large-scale survey
null
Resources
31 total interaction(s) for 30 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 5
  • Co-purification: 2
  • PCA: 3

Genetic Interactions
  • Negative Genetic: 8
  • Positive Genetic: 2
  • Synthetic Lethality: 10
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 298
Molecular Weight (Da) 32,991
Isoelectric Point (pI) 10.46
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:827873 to 826977 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..897 827873..826977 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB
Primary SGDIDS000004340
References cited on this page View Complete Literature Guide for DIC1
1) Epstein CB, et al.  (2001) Genome-wide responses to mitochondrial dysfunction. Mol Biol Cell 12(2):297-308
2) Kakhniashvili D, et al.  (1997) Identification of a novel gene encoding the yeast mitochondrial dicarboxylate transport protein via overexpression, purification, and characterization of its protein product. J Biol Chem 272(7):4516-21
3) Palmieri L, et al.  (1999) The mitochondrial dicarboxylate carrier is essential for the growth of Saccharomyces cerevisiae on ethanol or acetate as the sole carbon source. Mol Microbiol 31(2):569-77
4) Fiermonte G, et al.  (1998) The sequence, bacterial expression, and functional reconstitution of the rat mitochondrial dicarboxylate transporter cloned via distant homologs in yeast and Caenorhabditis elegans. J Biol Chem 273(38):24754-9