KAP95/YLR347C Summary Help

KAP95 BASIC INFORMATION

Standard Name KAP95 1
Systematic Name YLR347C
Alias RSL1
Feature Type ORF, Verified
Description Karyopherin beta, forms a complex with Srp1p/Kap60p; interacts with nucleoporins to mediate nuclear import of NLS-containing cargo proteins via the nuclear pore complex; regulates PC biosynthesis; GDP-to-GTP exchange factor for Gsp1p (1, 2, 3, 4, 5)
Name Description KAryoPherin 1
GO Annotations All KAP95 GO evidence and references
    View Computational GO annotations for KAP95
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All KAP95 Phenotype details and references
Classical genetics
conditional
unspecified
Large-scale survey
null
Interactions KAP95 All interactions details and references
254 total interaction(s) for 118 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 131
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 46
  • Co-crystal Structure: 1
  • Co-fractionation: 1
  • Co-purification: 3
  • PCA: 4
  • Protein-peptide: 2
  • Protein-RNA: 1
  • Reconstituted Complex: 33
  • Two-hybrid: 11
Genetic Interactions
  • Phenotypic Enhancement: 8
  • Phenotypic Suppression: 7
  • Synthetic Lethality: 5
Sequence Information
ChrXII:826412 to 823827 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
This feature contains embedded feature(s): YLR347W-A
Gbrowse
Last Update Coordinates: 2004-02-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2586 826412..823827 2004-02-05 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000004339

KAP95 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for KAP95

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for KAP95]

1) Enenkel C, et al.  (1995) Identification of a yeast karyopherin heterodimer that targets import substrate to mammalian nuclear pore complexes. J Biol Chem 270(28):16499-502
2) Aitchison JD, et al.  (1996) Kap104p: a karyopherin involved in the nuclear transport of messenger RNA binding proteins. Science 274(5287):624-7
3) Gilchrist D and Rexach M  (2003) Molecular basis for the rapid dissociation of nuclear localization signals from karyopherin alpha in the nucleoplasm. J Biol Chem 278(51):51937-49
4) Mackinnon MA, et al.  (2009) The kap60-kap95 karyopherin complex directly regulates phosphatidylcholine synthesis. J Biol Chem 284(11):7376-84
5) Lonhienne TG, et al.  (2009) Importin-{beta} Is a GDP-to-GTP Exchange Factor of Ran: IMPLICATIONS FOR THE MECHANISM OF NUCLEAR IMPORT. J Biol Chem 284(34):22549-58