VRP1/YLR337C Summary Help

VRP1 BASIC INFORMATION

Standard Name VRP1 1
Systematic Name YLR337C
Alias END5 , MDP2 , YLR337W
Feature Type ORF, Verified
Description Proline-rich actin-associated protein involved in cytoskeletal organization and cytokinesis; related to mammalian Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP) (1, 2, 3)
Name Description VeRProlin 1
Gene Product Alias verprolin 4
GO Annotations All VRP1 GO evidence and references
    View Computational GO annotations for VRP1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All VRP1 Phenotype details and references
Classical genetics
conditional
null
Large-scale survey
null
Interactions VRP1 All interactions details and references
171 total interaction(s) for 104 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 9
  • Affinity Capture-Western: 4
  • Co-localization: 2
  • Far Western: 1
  • PCA: 13
  • Protein-RNA: 1
  • Reconstituted Complex: 5
  • Two-hybrid: 30
Genetic Interactions
  • Dosage Rescue: 5
  • Phenotypic Enhancement: 46
  • Phenotypic Suppression: 11
  • Synthetic Growth Defect: 13
  • Synthetic Lethality: 29
  • Synthetic Rescue: 2
Sequence Information
ChrXII:805106 to 802653 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2004-02-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2454 805106..802653 2004-02-05 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000004329

VRP1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for VRP1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for VRP1]

1) Donnelly SF, et al.  (1993) A proline-rich protein, verprolin, involved in cytoskeletal organization and cellular growth in the yeast Saccharomyces cerevisiae. Mol Microbiol 10(3):585-96
2) Munn AL, et al.  (1995) end5, end6, and end7: mutations that cause actin delocalization and block the internalization step of endocytosis in Saccharomyces cerevisiae. Mol Biol Cell 6(12):1721-42
3) Thanabalu T and Munn AL  (2001) Functions of Vrp1p in cytokinesis and actin patches are distinct and neither requires a WH2/V domain. EMBO J 20(24):6979-89
4) Roumanie O, et al.  (2000) Evidence for the genetic interaction between the actin-binding protein Vrp1 and the RhoGAP Rgd1 mediated through Rho3p and Rho4p in Saccharomyces cerevisiae. Mol Microbiol 36(6):1403-14