BUD6/YLR319C Summary

BUD6 BASIC INFORMATION

Standard Name	BUD6
Systematic Name	YLR319C
Alias	AIP3
Feature Type	ORF, Verified
Description	Actin- and formin-interacting protein, involved in actin cable nucleation and polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate (1, 2)
Name Description	BUD site selection

GO Annotations	All BUD6 GO evidence and references
	View Computational GO annotations for BUD6
Molecular Function
Manually curated	cytoskeletal regulatory protein binding (IPI)
Biological Process
Manually curated	actin filament organization (TAS) bipolar cellular bud site selection (TAS) cellular bud site selection (TAS) cytokinesis (TAS) establishment of cell polarity (TAS) extrachromosomal circular DNA localization during cell aging (IMP) response to osmotic stress (TAS) Rho protein signal transduction (TAS)
Cellular Component
Manually curated	actin cap (TAS) polarisome (TAS) spindle pole body (IDA)
High-throughput	mating projection tip (IDA)

Mutant Phenotype	All BUD6 Phenotype details and references
Classical genetics
null	actin cytoskeleton morphology: abnormal chromosome/plasmid maintenance: decreased lifespan: abnormal Bud8p-GFP distribution: abnormal
Large-scale survey
null	bud morphology: abnormal budding pattern: abnormal cell shape: abnormal hyperosmotic stress resistance: decreased resistance to ethanol: decreased viable

Interactions	BUD6 All interactions details and references
	66 total interaction(s) for 51 unique genes/features.
Physical Interactions	Affinity Capture-MS: 6 Biochemical Activity: 7 Co-localization: 1 PCA: 1 Reconstituted Complex: 3 Two-hybrid: 14
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 6 Phenotypic Enhancement: 7 Synthetic Growth Defect: 11 Synthetic Lethality: 7 Synthetic Rescue: 2

Sequence Information

ChrXII:771684 to 769318 | |

Note: this feature is encoded on the Crick strand.

Genetic position: 221 cM

Last Update

Coordinates: 2004-02-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2367	771684..769318	2004-02-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000004311

BUD6 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for BUD6

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for BUD6]

1)	Amberg DC, et al. (1997) Aip3p/Bud6p, a yeast actin-interacting protein that is involved in morphogenesis and the selection of bipolar budding sites. Mol Biol Cell 8(4):729-53
2)	Evangelista M, et al. (1997) Bni1p, a yeast formin linking cdc42p and the actin cytoskeleton during polarized morphogenesis. Science 276(5309):118-22

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