IMH1/YLR309C Summary Help

Standard Name IMH1 1
Systematic Name YLR309C
Alias SYS3 2
Feature Type ORF, Verified
Description Protein involved in vesicular transport; mediates transport between an endosomal compartment and the Golgi, contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi (3, 4, 5)
Name Description shares with Integrins and Myosins significant Homology 1
Chromosomal Location
ChrXII:751769 to 749034 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All IMH1 GO evidence and references
  View Computational GO annotations for IMH1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 2 genes
Large-scale survey
71 total interaction(s) for 50 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 6
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 4
  • Biochemical Activity: 1
  • Co-fractionation: 1
  • Co-localization: 1
  • FRET: 2
  • PCA: 1
  • Reconstituted Complex: 3
  • Two-hybrid: 27

Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 3
  • Negative Genetic: 12
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 1
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 3

Expression Summary
Length (a.a.) 911
Molecular Weight (Da) 105,224
Isoelectric Point (pI) 5.42
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrXII:751769 to 749034 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Last Update Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..2736 751769..749034 2011-02-03 2011-02-03
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004300
References cited on this page View Complete Literature Guide for IMH1
1) Li B and Warner JR  (1996) Mutation of the Rab6 homologue of Saccharomyces cerevisiae, YPT6, inhibits both early Golgi function and ribosome biosynthesis. J Biol Chem 271(28):16813-9
2) Tsukada M and Gallwitz D  (1996) Isolation and characterization of SYS genes from yeast, multicopy suppressors of the functional loss of the transport GTPase Ypt6p. J Cell Sci 109 ( Pt 10)():2471-81
3) Kjer-Nielsen L, et al.  (1999) A novel Golgi-localisation domain shared by a class of coiled-coil peripheral membrane proteins. Curr Biol 9(7):385-8
4) Tsukada M, et al.  (1999) Structural and functional analysis of a novel coiled-coil protein involved in Ypt6 GTPase-regulated protein transport in yeast. Mol Biol Cell 10(1):63-75
5) Setty SR, et al.  (2003) Golgi recruitment of GRIP domain proteins by Arf-like GTPase 1 is regulated by Arf-like GTPase 3. Curr Biol 13(5):401-4