Standard Name	ACO1
Systematic Name	YLR304C
Alias	GLU1
Feature Type	ORF, Verified
Description	Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy (1, 2, 3)
Name Description	ACOnitase 1

Chromosomal Location	ChrXII:737548 to 735212 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for ACO1
Molecular Function
Manually curated	aconitate hydratase activity (IDA, IMP) double-stranded DNA binding (IDA) single-stranded DNA binding (IDA)
Biological Process
Manually curated	mitochondrial genome maintenance (IMP) tricarboxylic acid cycle (IDA)
Cellular Component
Manually curated	cytosol (IDA) mitochondrial matrix (IDA) mitochondrial nucleoid (IDA)
High-throughput	mitochondrion (IDA)

Pathways	glyoxylate cycle superpathway of TCA cycle and glyoxylate cycle TCA cycle, aerobic respiration

Classical genetics
null	auxotrophy reactive oxygen species accumulation: increased iron molecular entity accumulation: increased chronological lifespan: decreased hyperosmotic stress resistance: decreased metal resistance: increased mitochondrial genome maintenance: abnormal Fum1p distribution: abnormal respiratory growth: absent utilization of carbon source: absent
unspecified	utilization of carbon source: absent
Large-scale survey
null	glycogen accumulation: decreased competitive fitness: decreased dessication resistance: decreased fermentative growth: decreased rate heat sensitivity: increased hyperosmotic stress resistance: decreased resistance to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO): decreased resistance to ethanol: decreased resistance to benomyl: decreased resistance to calcium dichloride: decreased resistance to doxorubicin: decreased resistance to BPS: increased resistance to elesclomol-Cu: decreased respiratory growth: absent respiratory growth: decreased rate toxin resistance: decreased utilization of carbon source: decreased utilization of nitrogen source: absent vacuolar morphology: abnormal vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	184 total interaction(s) for 163 unique genes/features.
Physical Interactions	Affinity Capture-MS: 29 Affinity Capture-RNA: 4 Affinity Capture-Western: 1 Co-localization: 1
Genetic Interactions	Dosage Growth Defect: 1 Dosage Lethality: 1 Dosage Rescue: 2 Negative Genetic: 96 Phenotypic Enhancement: 1 Phenotypic Suppression: 1 Positive Genetic: 36 Synthetic Growth Defect: 8 Synthetic Lethality: 2 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:737548 to 735212 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2337 737548..735212 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004295