YHC1/YLR298C Summary Help

Standard Name YHC1 1
Systematic Name YLR298C
Feature Type ORF, Verified
Description Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site (1, 2)
Name Description Yeast Homolog of human U1C 1
Gene Product Alias U1-C 3 , U1C 1
Chromosomal Location
ChrXII:725416 to 724721 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All YHC1 GO evidence and references
  View Computational GO annotations for YHC1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 7 genes
Resources
Large-scale survey
conditional
null
reduction of function
Resources
313 total interaction(s) for 249 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 76
  • Affinity Capture-RNA: 1
  • Co-purification: 1

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 138
  • Positive Genetic: 89
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 5

Resources
Expression Summary
histogram
Resources
Length (a.a.) 231
Molecular Weight (Da) 27,045
Isoelectric Point (pI) 10.92
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:725416 to 724721 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..696 725416..724721 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004289
References cited on this page View Complete Literature Guide for YHC1
1) Tang J, et al.  (1997) Identification and characterization of a yeast homolog of U1 snRNP-specific protein C. EMBO J 16(13):4082-91
2) Zhang D and Rosbash M  (1999) Identification of eight proteins that cross-link to pre-mRNA in the yeast commitment complex. Genes Dev 13(5):581-92
3) Neubauer G, et al.  (1997) Identification of the proteins of the yeast U1 small nuclear ribonucleoprotein complex by mass spectrometry. Proc Natl Acad Sci U S A 94(2):385-90