SEC72/YLR292C Summary

SEC72 BASIC INFORMATION

Standard Name	SEC72
Systematic Name	YLR292C
Alias	SEC67 , SIM2
Feature Type	ORF, Verified
Description	Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER (1)
Name Description	SECretory

GO Annotations	All SEC72 GO evidence and references
	View Computational GO annotations for SEC72
Molecular Function
Manually curated	protein transporter activity (TAS)
Biological Process
Manually curated	posttranslational protein targeting to membrane, translocation (IDA)
Cellular Component
Manually curated	endoplasmic reticulum membrane (TAS) Sec62/Sec63 complex (IPI)

Mutant Phenotype	All SEC72 Phenotype details and references
Classical genetics
null	carboxypeptidase Y secretion: decreased viable
Large-scale survey
null	resistance to hydroxyurea: decreased viable

Interactions	SEC72 All interactions details and references
	75 total interaction(s) for 44 unique genes/features.
Physical Interactions	Affinity Capture-MS: 11 Affinity Capture-RNA: 1 Affinity Capture-Western: 2 Co-purification: 4 Two-hybrid: 22
Genetic Interactions	Phenotypic Enhancement: 26 Phenotypic Suppression: 1 Synthetic Growth Defect: 4 Synthetic Lethality: 4

Sequence Information

ChrXII:720372 to 719791 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2004-02-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..582	720372..719791	2004-02-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000004283

SEC72 RESOURCES

Click on map for expanded view

SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for SEC72

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SEC72]

1)	Young BP, et al. (2001) Sec63p and Kar2p are required for the translocation of SRP-dependent precursors into the yeast endoplasmic reticulum in vivo. EMBO J 20(1-2):262-71

SGD^tm pages Database Copyright © 1997-2010 The Board of Trustees of Leland Stanford Junior University. Permission to use the information contained in this database was given by the researchers/institutes who contributed or published the information. Users of the database are solely responsible for compliance with any copyright restrictions, including those applying to the author abstracts. Documents from this server are provided "AS-IS" without any warranty, expressed or implied. The SGD project at Stanford University is supported by a Genome Research Resource Grant from the US National Human Genome Research Institute, part of the US National Institutes of Health.