GUF1/YLR289W Summary Help

Standard Name GUF1 1
Systematic Name YLR289W
Feature Type ORF, Verified
Description Mitochondrial matrix GTPase; associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor (1, 2)
Name Description Gtpase of Unknown Function 1
Chromosomal Location
ChrXII:715089 to 717026 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All GUF1 GO evidence and references
  View Computational GO annotations for GUF1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 4 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
17 total interaction(s) for 16 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Affinity Capture-RNA: 1

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 3
  • Positive Genetic: 2
  • Synthetic Growth Defect: 5
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 645
Molecular Weight (Da) 73,188
Isoelectric Point (pI) 9.95
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:715089 to 717026 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1938 715089..717026 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004280
References cited on this page View Complete Literature Guide for GUF1
1) Kiser GL and Weinert TA  (1995) GUF1, a gene encoding a novel evolutionarily conserved GTPase in budding yeast. Yeast 11(13):1311-6
2) Bauerschmitt H, et al.  (2008) The Membrane-bound GTPase Guf1 Promotes Mitochondrial Protein Synthesis under Suboptimal Conditions. J Biol Chem 283(25):17139-46