Standard Name	GUF1
Systematic Name	YLR289W
Feature Type	ORF, Verified
Description	Mitochondrial matrix GTPase that associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor (1, 2)
Name Description	Gtpase of Unknown Function 1

Chromosomal Location	ChrXII:715089 to 717026 | ORF Map | GBrowse

	View Computational GO annotations for GUF1
Molecular Function
Manually curated	GTPase activity (IDA, ISS) ribosome binding (IDA)
Biological Process
Manually curated	positive regulation of translation (IMP)
Cellular Component
Manually curated	mitochondrial matrix (IDA) colocalizes_with mitochondrial ribosome (IDA)
High-throughput	mitochondrion (IDA)

Classical genetics
null	respiratory growth: decreased rate respiratory growth: normal rate toxin resistance: increased
Large-scale survey
null	competitive fitness: increased haploinsufficient hyperosmotic stress resistance: decreased mitochondrial genome maintenance: abnormal resistance to sirolimus: decreased resistance to ethanol: decreased resistance to wortmannin: normal stress resistance: increased transposable element transposition: decreased vacuolar morphology: abnormal viable
overexpression	resistance to LY-83583: increased resistance to sirolimus: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	17 total interaction(s) for 16 unique genes/features.
Physical Interactions	Affinity Capture-MS: 4 Affinity Capture-RNA: 1
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 3 Positive Genetic: 2 Synthetic Growth Defect: 5 Synthetic Lethality: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:715089 to 717026 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1938 715089..717026 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004280