NNT1/YLR285W Summary Help

Standard Name NNT1 1
Systematic Name YLR285W
Feature Type ORF, Verified
Description S-adenosylmethionine-dependent methyltransferase; has a role in rDNA silencing and in lifespan determination (1, 2)
Name Description Nicotinamide N-methylTransferase
Chromosomal Location
ChrXII:707360 to 708145 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All NNT1 GO evidence and references
  View Computational GO annotations for NNT1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 4 genes
Resources
Large-scale survey
null
Resources
24 total interaction(s) for 24 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 6
  • Biochemical Activity: 1
  • Reconstituted Complex: 2

Genetic Interactions
  • Negative Genetic: 8
  • Positive Genetic: 5
  • Synthetic Growth Defect: 1
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 261
Molecular Weight (Da) 29,632
Isoelectric Point (pI) 4.88
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:707360 to 708145 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..786 707360..708145 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004275
References cited on this page View Complete Literature Guide for NNT1
1) Anderson RM, et al.  (2003) Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae. Nature 423(6936):181-5
2) Wlodarski T, et al.  (2011) Comprehensive Structural and Substrate Specificity Classification of the Saccharomyces cerevisiae Methyltransferome. PLoS One 6(8):e23168