DCS1/YLR270W Summary

DCS1 BASIC INFORMATION

Standard Name	DCS1 1
Systematic Name	YLR270W
Feature Type	ORF, Verified
Description	Non-essential hydrolase involved in mRNA decapping, may function in a feedback mechanism to regulate deadenylation, contains pyrophosphatase activity and a HIT (histidine triad) motif; interacts with neutral trehalase Nth1p (2, 3) Also known as: DcpS
Name Description	DeCapping Scavenger 1, 3

GO Annotations	All DCS1 GO evidence and references
	View Computational GO annotations for DCS1
Molecular Function
Manually curated	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (IDA, IMP, ISS) m7G(5')pppN diphosphatase activity (IDA)
Biological Process
Manually curated	deadenylation-dependent decapping of nuclear-transcribed mRNA (IDA, IMP, ISS) nuclear-transcribed mRNA catabolic process, deadenylation-independent decay (IGI, IMP)
Cellular Component
Manually curated	cytoplasmic mRNA processing body (IDA)
High-throughput	cytoplasm (IDA) mitochondrion (IDA) nucleus (IDA)

Mutant Phenotype	All DCS1 Phenotype details and references
Classical genetics
null	mRNA accumulation: increased survival rate in stationary phase: decreased
Large-scale survey
null	glycogen accumulation: decreased competitive fitness: decreased heat sensitivity: increased hyperosmotic stress resistance: decreased resistance to 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid: decreased resistance to trichothecene: increased respiratory growth: decreased rate respiratory growth: absent utilization of carbon source: decreased viable

Interactions	DCS1 All interactions details and references
	View additional details at BioGRID
	22 total interaction(s) for 19 unique genes/features.
Physical Interactions	Affinity Capture-MS: 7 Affinity Capture-RNA: 1 Affinity Capture-Western: 1 Biochemical Activity: 1 PCA: 1 Two-hybrid: 2
Genetic Interactions	Negative Genetic: 5 Positive Genetic: 3 Synthetic Lethality: 1

Sequence Information

ChrXII:681188 to 682240 | |

Last Update

Coordinates: 2004-02-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1053	681188..682240	2004-02-05	1996-07-31

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000004260

DCS1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for DCS1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for DCS1]

1)	Kwasnicka DA, et al. (2003) Coordinate expression of NADPH-dependent flavin reductase, Fre-1, and Hint-related 7meGMP-directed hydrolase, DCS-1. J Biol Chem 278(40):39051-8
2)	Souza AC, et al. (2002) Evidence for a modulation of neutral trehalase activity by Ca2+ and cAMP signaling pathways in Saccharomyces cerevisiae. Braz J Med Biol Res 35(1):11-6
3)	Liu H, et al. (2002) The scavenger mRNA decapping enzyme DcpS is a member of the HIT family of pyrophosphatases. EMBO J 21(17):4699-708

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