Standard Name	HAP1 (see Nomenclature conflict Note)
Systematic Name	YLR256W
Alias	CYP1 1
Feature Type	ORF, Verified
Description	Zinc finger transcription factor involved in the complex regulation of gene expression in response to levels of heme and oxygen; the S288C sequence differs from other strain backgrounds due to a Ty1 insertion in the carboxy terminus (2, 3, 4, 5, 6)
Name Description	Heme Activator Protein 3, 7

Chromosomal Location	ChrXII:646415 to 650923 | ORF Map | GBrowse

	View Computational GO annotations for HAP1
Molecular Function
Manually curated	RNA polymerase II core promoter proximal region sequence-specific DNA binding (IDA) RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (IDA, IMP) sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity (IC)
High-throughput	sequence-specific DNA binding (IDA)
Biological Process
Manually curated	carbon catabolite activation of transcription from RNA polymerase II promoter (IMP) establishment of protein localization to chromatin (IMP) negative regulation of transcription from RNA polymerase II promoter in response to hypoxia (IMP) regulation of cellular respiration (IGI, IMP)
Cellular Component
Manually curated	nucleus (IDA)

Binding motifs	Predicted HAP1 Binding Site Locations
	CGGABWTW 8 [Search intergenic regions for CGGABWTW] CGGNNNTANCGG 9 [Search intergenic regions for CGGNNNTANCGG] GGNNATANCGS 10 [Search intergenic regions for GGNNATANCGS]
Resources	ScerTF | YEASTRACT | YeTFaSCo

Classical genetics
reduction of function	mitochondrial rho- mutation frequency: increased Zn porphyrin accumulation: increased cytochrome accumulation: decreased
Large-scale survey
null	anaerobic growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	29 total interaction(s) for 24 unique genes/features.
Physical Interactions	Affinity Capture-MS: 6 Affinity Capture-RNA: 2 Affinity Capture-Western: 4 Biochemical Activity: 1 Reconstituted Complex: 4 Two-hybrid: 2
Genetic Interactions	Phenotypic Enhancement: 2 Synthetic Lethality: 2 Synthetic Rescue: 6
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:646415 to 650923 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..4509 646415..650923 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004246