Standard Name	RCK2 1
Systematic Name	YLR248W
Alias	CLK1 2 , CMK3 3
Feature Type	ORF, Verified
Description	Protein kinase involved in response to oxidative and osmotic stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; similar to CaM (calmodulin) kinases; RCK2 has a paralog, RCK1, that arose from the whole genome duplication (2, 4, 5, 6, 7)
Name Description	Radiation sensitivity Complementing Kinase 1

Chromosomal Location	ChrXII:634252 to 636084 | ORF Map | GBrowse

	View Computational GO annotations for RCK2
Molecular Function
Manually curated	protein serine/threonine kinase activity (IDA, ISS)
High-throughput	protein kinase activity (IDA)
Biological Process
Manually curated	cellular response to oxidative stress (IMP) osmosensory signaling pathway (IGI, IMP, IPI) protein phosphorylation (IDA, ISS) regulation of meiosis (IGI, IMP)
High-throughput	protein phosphorylation (IDA)
Cellular Component
Manually curated	cytoplasm (IDA)
High-throughput	cytoplasm (IDA)

Classical genetics
null	meiotic recombination: normal resistance to sirolimus: decreased viable
Large-scale survey
null	competitive fitness: increased hyperosmotic stress resistance: decreased resistance to spermine: decreased resistance to benzo[a]pyrene: decreased resistance to hygromycin B: decreased viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	103 total interaction(s) for 79 unique genes/features.
Physical Interactions	Affinity Capture-MS: 13 Affinity Capture-RNA: 2 Affinity Capture-Western: 7 Biochemical Activity: 28 PCA: 3 Reconstituted Complex: 5 Two-hybrid: 5
Genetic Interactions	Dosage Lethality: 3 Dosage Rescue: 9 Negative Genetic: 12 Phenotypic Enhancement: 1 Phenotypic Suppression: 1 Positive Genetic: 7 Synthetic Growth Defect: 2 Synthetic Haploinsufficiency: 2 Synthetic Rescue: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:634252 to 636084 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1833 634252..636084 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004238