GPN3/YLR243W Summary Help

Standard Name GPN3 1
Systematic Name YLR243W
Feature Type ORF, Verified
Description Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; may have a role in sister chromatid cohesion; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn2p (2, 3, 4)
Name Description Gly-Pro-Asn (N) motif 1
Chromosomal Location
ChrXII:624203 to 625021 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All GPN3 GO evidence and references
  View Computational GO annotations for GPN3
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Resources
Classical genetics
conditional
Large-scale survey
null
overexpression
reduction of function
Resources
17 total interaction(s) for 15 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Affinity Capture-Western: 1
  • Co-purification: 1
  • Two-hybrid: 4

Genetic Interactions
  • Dosage Growth Defect: 1
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 272
Molecular Weight (Da) 30,653
Isoelectric Point (pI) 4.21
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:624203 to 625021 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..819 624203..625021 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004233
References cited on this page View Complete Literature Guide for GPN3
1) Alonso B, et al.  (2011) A role for GPN-loop GTPase yGPN1 in sister chromatid cohesion. Cell Cycle 10(11):1828-37
2) Giaever G, et al.  (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91
3) Minaker SW, et al.  (2013) Biogenesis of RNA Polymerases II and III Requires the Conserved GPN Small GTPases in Saccharomyces cerevisiae. Genetics 193(3):853-64
4) Alonso B, et al.  (2013) Eukaryotic GPN-loop GTPases paralogs use a dimeric assembly reminiscent of archeal GPN. Cell Cycle 12(3):463-72