Standard Name	CCC1
Systematic Name	YLR220W
Feature Type	ORF, Verified
Description	Putative vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation; relative distribution to the vacuole decreases upon DNA replication stress (1, 2, 3, 4)
Name Description	Cross-Complements Ca(2+) phenotype of csg1 5

Chromosomal Location	ChrXII:576825 to 577793 | ORF Map | GBrowse

	View Computational GO annotations for CCC1
Molecular Function
Manually curated	ferrous iron transmembrane transporter activity (IMP) manganese ion transmembrane transporter activity (IMP)
Biological Process
Manually curated	cellular calcium ion homeostasis (IGI, IMP) cellular iron ion homeostasis (IGI, IMP) cellular manganese ion homeostasis (IGI, IMP) ferrous iron transport (IMP) manganese ion transport (IMP)
Cellular Component
Manually curated	fungal-type vacuole membrane (IDA) Golgi apparatus (IDA)
High-throughput	fungal-type vacuole membrane (IDA) integral to membrane (ISM)

Classical genetics
null	reactive oxygen species accumulation: increased metal resistance: decreased
Large-scale survey
null	competitive fitness: decreased haploinsufficient resistance to benzo[a]pyrene: decreased resistance to cycloheximide: decreased resistance to benzo[a]pyrene: increased sporulation: normal viable
overexpression	cell cycle progression: abnormal inviable vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	48 total interaction(s) for 38 unique genes/features.
Physical Interactions	Affinity Capture-MS: 4 Biochemical Activity: 1 PCA: 1 Two-hybrid: 1
Genetic Interactions	Dosage Growth Defect: 1 Dosage Lethality: 3 Dosage Rescue: 17 Negative Genetic: 4 Phenotypic Enhancement: 4 Phenotypic Suppression: 2 Positive Genetic: 5 Synthetic Growth Defect: 3 Synthetic Lethality: 1 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:576825 to 577793 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..969 576825..577793 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004210