Standard Name	COA4 1
Systematic Name	YLR218C
Alias	CMC3 2
Feature Type	ORF, Verified
Description	Twin Cx(9)C protein involved in cytochrome c oxidase assembly or stability; localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; interacts genetically with CYC1 and with cytochrome c oxidase assembly factors (1, 2, 3)
Name Description	Cytochrome Oxidase Assembly factor 1

Chromosomal Location	ChrXII:573918 to 573466 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for COA4
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	mitochondrial respiratory chain complex assembly (IMP) mitochondrial respiratory chain complex IV assembly (IGI, IMP)
Cellular Component
Manually curated	mitochondrial intermembrane space (IDA)
High-throughput	cytoplasm (IDA) nucleus (IDA)

Classical genetics
null	copper accumulation: decreased cytochrome c reductase activity: decreased cytochrome c oxidase activity: decreased respiratory growth: decreased
Large-scale survey
null	glycogen accumulation: decreased competitive fitness: decreased dessication resistance: decreased haploinsufficient resistance to tunicamycin: decreased resistance to methyl methanesulfonate: decreased resistance to benzo[a]pyrene: increased resistance to hydroxyurea: decreased respiratory growth: absent respiratory growth: decreased respiratory growth: decreased rate utilization of carbon source: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	121 total interaction(s) for 91 unique genes/features.
Physical Interactions	Affinity Capture-MS: 5 Affinity Capture-RNA: 4
Genetic Interactions	Dosage Rescue: 3 Negative Genetic: 106 Positive Genetic: 2 Synthetic Growth Defect: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:573918 to 573466 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..453 573918..573466 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004208