Standard Name	HRD3 1
Systematic Name	YLR207W
Feature Type	ORF, Verified
Description	Resident protein of the ER membrane that plays a central role in ER-associated protein degradation (ERAD), forms HRD complex with Hrd1p and ERAD determinants that engages in lumen to cytosol communication and coordination of ERAD events (2)
Name Description	HMG-coA Reductase Degradation 1

Chromosomal Location	ChrXII:556788 to 559289 | ORF Map | GBrowse

	View Computational GO annotations for HRD3
Molecular Function
Manually curated	contributes_to ubiquitin-protein ligase activity (IDA)
Biological Process
Manually curated	ER-associated protein catabolic process (IDA)
Cellular Component
Manually curated	endoplasmic reticulum membrane (IPI) Hrd1p ubiquitin ligase ERAD-L complex (IDA) Hrd1p ubiquitin ligase ERAD-M complex (IDA) luminal surveillance complex (IDA)

Classical genetics
null	Golgi morphology: abnormal endoplasmic reticulum morphology: abnormal Kar2p secretion: abnormal mutant carboxypeptidase Y (CPY*) accumulation: increased
Large-scale survey
null	competitive fitness: increased resistance to sorbate: increased stress resistance: increased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	161 total interaction(s) for 70 unique genes/features.
Physical Interactions	Affinity Capture-MS: 7 Affinity Capture-Western: 27 Co-fractionation: 1 PCA: 3 Reconstituted Complex: 3
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 2 Negative Genetic: 23 Phenotypic Enhancement: 29 Phenotypic Suppression: 22 Positive Genetic: 39 Synthetic Growth Defect: 2 Synthetic Lethality: 1 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:556788 to 559289 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2502 556788..559289 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004197