Standard Name	NOP56 1
Systematic Name	YLR197W
Alias	SIK1 2
Feature Type	ORF, Verified
Description	Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects (1, 3, 4, 5)
Name Description	NucleOlar Protein of 56.8 kDa 1

Chromosomal Location	ChrXII:546097 to 547611 | ORF Map | GBrowse

	View Computational GO annotations for NOP56
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	rRNA modification (TAS) rRNA processing (IMP)
Cellular Component
Manually curated	box C/D snoRNP complex (IDA, IPI) nucleolus (IDA) small-subunit processome (IDA)
High-throughput	90S preribosome (IDA) nucleolus (IDA) nucleus (IDA)

Classical genetics
null	inviable resistance to nelfinavir: decreased
overexpression	budding index: increased cell size: increased pheromone sensitivity: normal spindle morphology: abnormal
repressible	box C/D snoRNA construct derived from U14 (snR128) localization: abnormal box C/D family U14 snoRNA localization: abnormal inviable
Large-scale survey
conditional	heat sensitivity: increased
null	competitive fitness: decreased haploinsufficient inviable starvation resistance: decreased
reduction of function	competitive fitness: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	232 total interaction(s) for 163 unique genes/features.
Physical Interactions	Affinity Capture-MS: 152 Affinity Capture-RNA: 4 Affinity Capture-Western: 11 PCA: 1 Two-hybrid: 10
Genetic Interactions	Dosage Lethality: 3 Negative Genetic: 17 Positive Genetic: 29 Synthetic Growth Defect: 2 Synthetic Lethality: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Mass Spec

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:546097 to 547611 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1515 546097..547611 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004187