NOP56/YLR197W Summary Help

NOP56 BASIC INFORMATION

Standard Name NOP56 1
Systematic Name YLR197W
Alias SIK1 2
Feature Type ORF, Verified
Description Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects (1, 3, 4, 5)
Name Description NucleOlar Protein of 56.8 kDa 1
GO Annotations All NOP56 GO evidence and references
    View Computational GO annotations for NOP56
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All NOP56 Phenotype details and references
Classical genetics
null
overexpression
repressible
Large-scale survey
conditional
null
Interactions NOP56 All interactions details and references
194 total interaction(s) for 137 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 129
  • Affinity Capture-Western: 5
  • Two-hybrid: 10
Genetic Interactions
  • Dosage Lethality: 2
  • Phenotypic Enhancement: 17
  • Phenotypic Suppression: 29
  • Synthetic Lethality: 2
Sequence Information
ChrXII:546099 to 547613 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1515 546099..547613 1996-07-31 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000004187

NOP56 RESOURCES

Click on map for expanded view
SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for NOP56

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for NOP56]

1) Gautier T, et al.  (1997) Nucleolar KKE/D repeat proteins Nop56p and Nop58p interact with Nop1p and are required for ribosome biogenesis. Mol Cell Biol 17(12):7088-98
2) Morin PJ, et al.  (1995) Genetic analysis of growth inhibition by GAL4-L kappa B-alpha in Saccharomyces cerevisiae. Cell Growth Differ 6(7):789-98
3) Lafontaine DL and Tollervey D  (2000) Synthesis and assembly of the box C+D small nucleolar RNPs. Mol Cell Biol 20(8):2650-9
4) Bogomolnaya LM, et al.  (2004) A new enrichment approach identifies genes that alter cell cycle progression in Saccharomyces cerevisiae. Curr Genet 45(6):350-9
5) Hayano T, et al.  (2003) Proteomic analysis of human Nop56p-associated pre-ribosomal ribonucleoprotein complexes. Possible link between Nop56p and the nucleolar protein treacle responsible for Treacher Collins syndrome. J Biol Chem 278(36):34309-19