NMT1/YLR195C Summary Help

Standard Name NMT1
Systematic Name YLR195C
Alias CDC72 1
Feature Type ORF, Verified
Description N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction (2, 3, 4, 5)
Name Description N-Myristoyl Transferase 5
Chromosomal Location
ChrXII:543304 to 541937 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: 142 cM
Gene Ontology Annotations All NMT1 GO evidence and references
  View Computational GO annotations for NMT1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Classical genetics
conditional
null
Large-scale survey
null
reduction of function
Resources
49 total interaction(s) for 46 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Affinity Capture-RNA: 3
  • Biochemical Activity: 4
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Rescue: 6
  • Negative Genetic: 16
  • Positive Genetic: 5
  • Synthetic Growth Defect: 4
  • Synthetic Lethality: 4
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:543304 to 541937 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Genetic position: 142 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1368 543304..541937 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004185
References cited on this page View Complete Literature Guide for NMT1
1) Reed SI, et al.  (1988) Isolation and characterization of two genes encoding yeast mating pheromone signaling elements: CDC72 and CDC73. Cold Spring Harb Symp Quant Biol 53 Pt 2:621-7
2) Knoll LJ, et al.  (1992) Analysis of the compartmentalization of myristoyl-CoA:protein N-myristoyltransferase in Saccharomyces cerevisiae. J Biol Chem 267(8):5366-73
3) Stone DE, et al.  (1991) N-myristoylation is required for function of the pheromone-responsive G alpha protein of yeast: conditional activation of the pheromone response by a temperature-sensitive N-myristoyl transferase. Genes Dev 5(11):1969-81
4) Duronio RJ, et al.  (1989) Disruption of the yeast N-myristoyl transferase gene causes recessive lethality. Science 243(4892):796-800
5) Towler DA, et al.  (1987) Amino-terminal processing of proteins by N-myristoylation. Substrate specificity of N-myristoyl transferase. J Biol Chem 262(3):1030-6