Standard Name	HCR1 1
Systematic Name	YLR192C
Feature Type	ORF, Verified
Description	Dual function protein involved in translation initiation as a substoichiometric component (eIF3j) of translation initiation factor 3 (eIF3) and required for processing of 20S pre-rRNA; binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNA (1, 2)
Name Description	High-Copy suppressor of Rpg1 1

Chromosomal Location	ChrXII:539589 to 538792 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for HCR1
Molecular Function
Manually curated	translation initiation factor activity (IPI, ISS)
Biological Process
Manually curated	cytoplasmic translation (IPI, ISS) maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) (IMP)
Cellular Component
Manually curated	eukaryotic translation initiation factor 3 complex (IPI)

Classical genetics
null	20S pre-rRNA modification: decreased rate resistance to paromomycin: decreased
Large-scale survey
null	alkaline pH resistance: decreased auxotrophy budding pattern: abnormal cell size: decreased competitive fitness: decreased dessication resistance: decreased heat sensitivity: increased ionic stress resistance: decreased resistance to cycloheximide: decreased resistance to paromomycin: decreased resistance to streptomycin: decreased resistance to benzo[a]pyrene: decreased resistance to sodium arsenite: increased resistance to mycophenolic acid: increased resistance to 4-chlorophenol: decreased resistance to caffeine: decreased resistance to fenpropimorph: decreased resistance to methyl methanesulfonate: decreased resistance to tunicamycin: decreased resistance to doxorubicin: decreased resistance to fluconazole: increased stress resistance: increased telomere length: decreased vacuolar morphology: abnormal vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	191 total interaction(s) for 132 unique genes/features.
Physical Interactions	Affinity Capture-MS: 39 Affinity Capture-RNA: 3 Affinity Capture-Western: 15 Biochemical Activity: 7 Co-crystal Structure: 1 Co-fractionation: 2 Protein-peptide: 6 Reconstituted Complex: 4 Two-hybrid: 3
Genetic Interactions	Dosage Growth Defect: 2 Dosage Rescue: 6 Negative Genetic: 42 Phenotypic Suppression: 2 Positive Genetic: 46 Synthetic Growth Defect: 9 Synthetic Lethality: 3 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:539589 to 538792 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..798 539589..538792 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004182