Standard Name	RFX1 (see Nomenclature conflict Note)
Systematic Name	YLR176C
Alias	CRT1 1
Feature Type	ORF, Verified
Description	Major transcriptional repressor of DNA-damage-regulated genes, recruits repressors Tup1p and Cyc8p to their promoters; involved in DNA damage and replication checkpoint pathway; similar to a family of mammalian DNA binding RFX1-4 proteins (1, 2, 3)

Chromosomal Location	ChrXII:510232 to 507797 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for RFX1
Molecular Function
Manually curated	RNA polymerase II core promoter proximal region sequence-specific DNA binding (IDA)
High-throughput	sequence-specific DNA binding (IDA)
Biological Process
Manually curated	negative regulation of transcription from RNA polymerase II promoter (IDA, IGI, IMP) positive regulation of transcription from RNA polymerase II promoter (IMP)
Cellular Component
High-throughput	cytoplasm (IDA) nucleus (IDA)

Binding motifs	Predicted RFX1 Binding Site Locations
	BGTTRCYA 4 [Search intergenic regions for BGTTRCYA] TCGCCATGGCAAC 5 [Search intergenic regions for TCGCCATGGCAAC] TTGCCATGGCAAC 6 [Search intergenic regions for TTGCCATGGCAAC]
Resources	ScerTF | YEASTRACT | YeTFaSCo

Classical genetics
null	UV resistance: increased mitochondrial genome maintenance: abnormal resistance to 4-nitroquinoline-1-oxide: increased resistance to selenite(2-): decreased resistance to methyl methanesulfonate: increased
Large-scale survey
null	cell cycle progression in G1 phase: delayed competitive fitness: decreased resistance to paromomycin: decreased resistance to cycloheximide: decreased resistance to amiodarone: decreased resistance to BPS: decreased stress resistance: decreased viable
overexpression	cell cycle progression: abnormal filamentous growth: increased vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	126 total interaction(s) for 98 unique genes/features.
Physical Interactions	Affinity Capture-MS: 14 Affinity Capture-RNA: 1 Reconstituted Complex: 7
Genetic Interactions	Dosage Growth Defect: 2 Dosage Lethality: 6 Dosage Rescue: 1 Negative Genetic: 55 Phenotypic Enhancement: 12 Phenotypic Suppression: 9 Positive Genetic: 3 Synthetic Growth Defect: 6 Synthetic Lethality: 1 Synthetic Rescue: 9
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:510232 to 507797 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2436 510232..507797 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004166