CBF5/YLR175W Summary Help

CBF5 BASIC INFORMATION

Standard Name CBF5
Systematic Name YLR175W
Feature Type ORF, Verified
Description Pseudouridine synthase catalytic subunit of box H/ACA small nucleolar ribonucleoprotein particles (snoRNPs), acts on both large and small rRNAs and on snRNA U2; mutations in human ortholog dyskerin cause the disorder dyskeratosis congenita (1, 2, 3, 4)
Name Description Centromere Binding Factor
GO Annotations All CBF5 GO evidence and references
    View Computational GO annotations for CBF5
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All CBF5 Phenotype details and references
Classical genetics
null
Large-scale survey
conditional
null
Interactions CBF5 All interactions details and references
165 total interaction(s) for 97 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 140
  • Affinity Capture-Western: 6
  • Co-purification: 1
  • Protein-peptide: 1
  • Reconstituted Complex: 7
  • Two-hybrid: 4
Genetic Interactions
  • Dosage Rescue: 2
  • Phenotypic Suppression: 2
  • Synthetic Lethality: 2
Sequence Information
ChrXII:506136 to 507587 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1452 506136..507587 1996-07-31 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000004165

CBF5 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for CBF5

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CBF5]

1) Heiss NS, et al.  (1998) X-linked dyskeratosis congenita is caused by mutations in a highly conserved gene with putative nucleolar functions. Nat Genet 19(1):32-8
2) Lafontaine DL, et al.  (1998) The box H + ACA snoRNAs carry Cbf5p, the putative rRNA pseudouridine synthase. Genes Dev 12(4):527-37
3) Henras AK, et al.  (2004) Cbf5p, the putative pseudouridine synthase of H/ACA-type snoRNPs, can form a complex with Gar1p and Nop10p in absence of Nhp2p and box H/ACA snoRNAs. RNA 10(11):1704-12
4) Ma X, et al.  (2005) Pseudouridylation of yeast U2 snRNA is catalyzed by either an RNA-guided or RNA-independent mechanism. EMBO J 24(13):2403-13