SEC10/YLR166C Summary Help

SEC10 BASIC INFORMATION

Standard Name SEC10 1
Systematic Name YLR166C
Feature Type ORF, Verified
Description Essential 100kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis (2, 3)
Name Description SECretory 4
GO Annotations All SEC10 GO evidence and references
    View Computational GO annotations for SEC10
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All SEC10 Phenotype details and references
Classical genetics
conditional
reduction of function
Large-scale survey
null
repressible
Interactions SEC10 All interactions details and references
167 total interaction(s) for 75 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 79
  • Affinity Capture-Western: 16
  • Co-fractionation: 1
  • Co-purification: 1
  • PCA: 1
  • Reconstituted Complex: 7
  • Two-hybrid: 6
Genetic Interactions
  • Dosage Lethality: 8
  • Dosage Rescue: 8
  • Phenotypic Enhancement: 2
  • Synthetic Growth Defect: 5
  • Synthetic Lethality: 32
  • Synthetic Rescue: 1
Sequence Information
ChrXII:498046 to 495431 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2616 498046..495431 1996-07-31 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000004156

SEC10 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for SEC10

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SEC10]

1) Novick P, et al.  (1980) Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway. Cell 21(1):205-15
2) Finger FP and Novick P  (1998) Spatial regulation of exocytosis: lessons from yeast. J Cell Biol 142(3):609-12
3) TerBush DR, et al.  (1996) The Exocyst is a multiprotein complex required for exocytosis in Saccharomyces cerevisiae. EMBO J 15(23):6483-94
4) Novick P and Schekman R  (1979) Secretion and cell-surface growth are blocked in a temperature-sensitive mutant of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 76(4):1858-62