Standard Name	ACS2 1
Systematic Name	YLR153C
Feature Type	ORF, Verified
Description	Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions (2, 3, 4)
Name Description	Acetyl CoA Synthetase 5

Chromosomal Location	ChrXII:447575 to 445524 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for ACS2
Molecular Function
Manually curated	acetate-CoA ligase activity (IDA) acid-ammonia (or amide) ligase activity (IDA)
Biological Process
Manually curated	acetyl-CoA biosynthetic process (IDA) histone acetylation (IMP) replicative cell aging (IMP)
Cellular Component
Manually curated	cytosol (IDA) nucleolus (IDA) nucleus (IDA)

Pathways	acetate utilization ethanol degradation

Classical genetics
null	growth in exponential phase: decreased rate replicative lifespan: decreased resistance to phleomycin: increased silencing: decreased utilization of carbon source: decreased
Large-scale survey
null	haploinsufficient inviable
overexpression	cell cycle progression: abnormal resistance to sirolimus: increased vegetative growth: decreased rate
reduction of function	resistance to hydroxyurea: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	218 total interaction(s) for 184 unique genes/features.
Physical Interactions	Affinity Capture-MS: 44 Affinity Capture-RNA: 1 PCA: 2 Two-hybrid: 2
Genetic Interactions	Negative Genetic: 44 Phenotypic Enhancement: 1 Phenotypic Suppression: 1 Positive Genetic: 7 Synthetic Growth Defect: 66 Synthetic Lethality: 39 Synthetic Rescue: 11
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:447575 to 445524 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2052 447575..445524 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004143