Standard Name	NHA1 1
Systematic Name	YLR138W
Feature Type	ORF, Verified
Description	Na+/H+ antiporter involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH (1, 2)
Name Description	Na+/H+ Antiporter 1

Chromosomal Location	ChrXII:418437 to 421394 | ORF Map | GBrowse

	View Computational GO annotations for NHA1
Molecular Function
Manually curated	cation:cation antiporter activity (IMP, ISS) sodium:hydrogen antiporter activity (IDA)
Biological Process
Manually curated	cellular monovalent inorganic cation homeostasis (IMP) cellular potassium ion homeostasis (IMP) response to osmotic stress (IMP)
Cellular Component
Manually curated	membrane raft (IDA) plasma membrane (IDA)
High-throughput	integral to membrane (ISM)

Classical genetics
null	hyperosmotic stress resistance: decreased viable
reduction of function	osmotic stress resistance: decreased
Large-scale survey
null	acid pH resistance: decreased competitive fitness: decreased dessication resistance: decreased haploproficient resistance to tunicamycin: decreased resistance to 1,4-dithiothreitol: decreased resistance to L-canavanine: increased viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	58 total interaction(s) for 43 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 Affinity Capture-RNA: 2 Affinity Capture-Western: 3 Biochemical Activity: 1 Co-fractionation: 1 PCA: 5 Reconstituted Complex: 1
Genetic Interactions	Dosage Rescue: 7 Negative Genetic: 10 Phenotypic Enhancement: 6 Positive Genetic: 8 Synthetic Growth Defect: 10 Synthetic Lethality: 1 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:418437 to 421394 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2958 418437..421394 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB

Primary SGDID	S000004128