ZRT2/YLR130C Summary

Standard Name	ZRT2 1
Systematic Name	YLR130C
Feature Type	ORF, Verified
Description	Low-affinity zinc transporter of the plasma membrane; transcription is induced under low-zinc conditions by the Zap1p transcription factor (1, 2 and see Summary Paragraph)
Name Description	Zinc-Regulated Transporter 1

Chromosomal Location	ChrXII:404062 to 402794 \| ORF Map \| GBrowse
	Note: this feature is encoded on the Crick strand.

Gene Ontology Annotations All ZRT2 GO evidence and references

	View Computational GO annotations for ZRT2
Molecular Function
Manually curated	low-affinity zinc ion transmembrane transporter activity (IMP, ISS)
Biological Process
Manually curated	low-affinity zinc ion transport (IMP, ISS)
Cellular Component
Manually curated	plasma membrane (IMP, ISS)
High-throughput	integral to membrane (ISM)

Mutant phenotypes All ZRT2 Phenotype evidence and references

Classical genetics
null	metal resistance: increased resistance to tellurite: decreased small molecule transport: increased viable
Large-scale survey
null	competitive fitness: decreased haploproficient vacuolar morphology: abnormal viable
Resources	PROPHECY \| SCMD \| ScreenTroll \| Yeast Fitness Database

interactions All ZRT2 Interaction evidence and references

	17 total interaction(s) for 11 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 2 Protein-RNA: 1
Genetic Interactions	Negative Genetic: 9 Phenotypic Enhancement: 3 Positive Genetic: 2
Resources	BioGRID \| BOND \| BioPIXIE \| CYC2008 (complexes) \| Complexome \| DIP \| DRYGIN \| GeneMANIA \| InterologFinder \| YeastRC Two-Hybrid

Expression Summary


Resources	Expression Summary \| Cell cycle and metabolic oscillation \| Cell cycle transcript profile \| Cyclebase \| Genevestigator \| GermOnline \| SPELL \| YMGV \| YeastFunc

Protein Information All ZRT2 Protein evidence and references

Localization	YeastRC \| YPL+ \| YeastGFP
Phosphorylation	PhosphoGRID \| PhosphoPep Database
Structure	GPMDB \| SCOP \| YeastRC
Homologs	Ashbya (AGD) \| AspGD Homologs \| CGD Homologs \| CandidaDB Homologs \| Fungal Orthogroups Repository \| P-POD \| PDB Homologs \| PhylomeDB \| YGOB \| YOGY

sequence information

ChrXII:404062 to 402794 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2011-02-03 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1269	404062..402794	2011-02-03	1996-07-31

Retrieve sequences

Analyze Sequence

S288C only	BLASTP \| ATCC/WashU Clones \| BLASTN \| Design Primers \| Restriction Fragment Map \| Restriction Fragment Sizes \| Six-Frame Translation
S288C vs. other species	Fungal Alignment \| BLASTN vs. fungi \| BLASTP at NCBI \| BLASTP vs. fungi \| Synteny Viewer
S288C vs. other strains	Strain Alignment

Resources

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| Search all NCBI (Entrez) \| TCDB \| UniProtKB

Primary SGDID	S000004120

SUMMARY PARAGRAPH for ZRT2

ZRT2 encodes a low-affinity zinc transporter (3). There are two systems for zinc uptake in yeast, one high-affinity and one lower-affinity (3). Zrt2p and the high-affinity zinc transporter Zrt1p are similar to each other, and are members of the ZIP family of heavy metal ion transporters (4). Zap1p is a transcriptional regulator that controls levels of ZRT1 and ZRT2 mRNAs in response to intracellular zinc levels (2).

Last updated: 2000-05-01

References cited on this page View Complete Literature Guide for ZRT2

1)	Zhao H and Eide D (1996) The ZRT2 gene encodes the low affinity zinc transporter in Saccharomyces cerevisiae. J Biol Chem 271(38):23203-10
2)	Zhao H and Eide DJ (1997) Zap1p, a metalloregulatory protein involved in zinc-responsive transcriptional regulation in Saccharomyces cerevisiae. Mol Cell Biol 17(9):5044-52
3)	Zhao H and Eide D (1996) The yeast ZRT1 gene encodes the zinc transporter protein of a high-affinity uptake system induced by zinc limitation. Proc Natl Acad Sci U S A 93(6):2454-8
4)	Eng BH, et al. (1998) Sequence analyses and phylogenetic characterization of the ZIP family of metal ion transport proteins. J Membr Biol 166(1):1-7