CFT2/YLR115W Summary Help

CFT2 BASIC INFORMATION

Standard Name CFT2 1
Systematic Name YLR115W
Alias YDH1 2
Feature Type ORF, Verified
Description Subunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with the mammalian CPSF-100 protein. (1, 2, 3)
Name Description Cleavage Factor Two
GO Annotations All CFT2 GO evidence and references
    View Computational GO annotations for CFT2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All CFT2 Phenotype details and references
Large-scale survey
conditional
null
Interactions CFT2 All interactions details and references
115 total interaction(s) for 30 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 91
  • Affinity Capture-Western: 5
  • Co-purification: 5
  • Reconstituted Complex: 9
  • Two-hybrid: 2
Genetic Interactions
  • Phenotypic Enhancement: 2
  • Synthetic Lethality: 1
Sequence Information
ChrXII:377986 to 380565 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2580 377986..380565 1996-07-31 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000004105

CFT2 RESOURCES

Click on map for expanded view
SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for CFT2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CFT2]

1) Zhao J, et al.  (1997) Cleavage factor II of Saccharomyces cerevisiae contains homologues to subunits of the mammalian Cleavage/ polyadenylation specificity factor and exhibits sequence-specific, ATP-dependent interaction with precursor RNA. J Biol Chem 272(16):10831-8
2) Preker PJ, et al.  (1997) A multisubunit 3' end processing factor from yeast containing poly(A) polymerase and homologues of the subunits of mammalian cleavage and polyadenylation specificity factor. EMBO J 16(15):4727-37
3) Kyburz A, et al.  (2003) The role of the yeast cleavage and polyadenylation factor subunit Ydh1p/Cft2p in pre-mRNA 3'-end formation. Nucleic Acids Res 31(14):3936-45