AHP1/YLR109W Summary Help

Standard Name AHP1 1
Systematic Name YLR109W
Feature Type ORF, Verified
Description Thiol-specific peroxiredoxin; reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p (1, 2, 3)
Name Description Alkyl HydroPeroxide reductase 1
Gene Product Alias cTPxIII
Chromosomal Location
ChrXII:368781 to 369311 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All AHP1 GO evidence and references
  View Computational GO annotations for AHP1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 12 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
74 total interaction(s) for 58 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 33
  • Affinity Capture-RNA: 11
  • Affinity Capture-Western: 4
  • Co-crystal Structure: 2
  • Co-purification: 1
  • PCA: 5
  • Reconstituted Complex: 1
  • Two-hybrid: 4

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 3
  • Positive Genetic: 1
  • Synthetic Growth Defect: 7
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 176
Molecular Weight (Da) 19,115
Isoelectric Point (pI) 4.87
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:368781 to 369311 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..531 368781..369311 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004099
References cited on this page View Complete Literature Guide for AHP1
1) Lee J, et al.  (1999) A new antioxidant with alkyl hydroperoxide defense properties in yeast. J Biol Chem 274(8):4537-44
2) Goehring AS, et al.  (2003) Attachment of the ubiquitin-related protein Urm1p to the antioxidant protein Ahp1p. Eukaryot Cell 2(5):930-6
3) Trivelli X, et al.  (2003) Characterization of the yeast peroxiredoxin Ahp1 in its reduced active and overoxidized inactive forms using NMR. Biochemistry 42(48):14139-49