LCL2/YLR104W Summary Help

Standard Name LCL2 1
Systematic Name YLR104W
Feature Type ORF, Uncharacterized
Description Putative protein of unknown function; mutant is deficient in amounts of cell wall mannosylphosphate and has long chronological lifespan; genetic interactions suggest a role in ER-associated protein degradation (ERAD) (1, 2, 3)
Name Description Long Chronological Lifespan 2 1
Chromosomal Location
ChrXII:346585 to 346980 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All LCL2 GO evidence and references
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Resources
Large-scale survey
null
overexpression
Resources
35 total interaction(s) for 23 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 1

Genetic Interactions
  • Negative Genetic: 7
  • Phenotypic Enhancement: 4
  • Phenotypic Suppression: 13
  • Positive Genetic: 7
  • Synthetic Growth Defect: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 131
Molecular Weight (Da) 14,922
Isoelectric Point (pI) 8.04
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:346585 to 346980 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..396 346585..346980 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004094
References cited on this page View Complete Literature Guide for LCL2
1) Matecic M, et al.  (2010) A microarray-based genetic screen for yeast chronological aging factors. PLoS Genet 6(4):e1000921
2) Conde R, et al.  (2003) Screening for new yeast mutants affected in mannosylphosphorylation of cell wall mannoproteins. Yeast 20(14):1189-211
3) Jonikas MC, et al.  (2009) Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum. Science 323(5922):1693-7